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Metabolic Engineering of Saccharomyces cerevisiae for Caffeine and Theobromine Production

Journal Article · · PLoS ONE
Research Organization:
Energy Frontier Research Centers (EFRC) (United States). Center for Advanced Biofuel Systems (CABS)
Sponsoring Organization:
USDOE SC Office of Basic Energy Sciences (SC-22)
DOE Contract Number:
SC0001295
OSTI ID:
1369674
Journal Information:
PLoS ONE, Journal Name: PLoS ONE Journal Issue: 8 Vol. 9; ISSN 1932-6203
Publisher:
Public Library of Science
Country of Publication:
United States
Language:
English

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Stepwise increase of resveratrol biosynthesis in yeast Saccharomyces cerevisiae by metabolic engineering journal September 2011
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The Endosymbiont Amoebophilus asiaticus Encodes an S-Adenosylmethionine Carrier That Compensates for Its Missing Methylation Cycle journal May 2013
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Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds journal February 2011
Purification and characterization of RihC, a xanthosine–inosine–uridine–adenosine-preferring hydrolase from Salmonella enterica serovar Typhimurium journal May 2005
The Structure of Two N -Methyltransferases from the Caffeine Biosynthetic Pathway journal April 2007
7-Methylxanthine Methyltransferase of Coffee Plants: GENE ISOLATION AND ENZYMATIC PROPERTIES journal December 2000
A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S -adenosyl- L -methionine cycle journal June 2001
Assessment of methylthioadenosine/S-adenosylhomocysteine nucleosidases of Borrelia burgdorferi as targets for novel antimicrobials using a novel high-throughput method journal April 2009
A LKALOID B IOSYNTHESIS IN P LANTS : Biochemistry, Cell Biology, Molecular Regulation, and Metabolic Engineering Applications journal June 2001
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Caffeine synthase gene from tea leaves journal August 2000
Caffeine and related purine alkaloids: Biosynthesis, catabolism, function and genetic engineering journal February 2008
Isolation of a new dual-functional caffeine synthase gene encoding an enzyme for the conversion of 7-methylxanthine to caffeine from coffee ( Coffea arabica L.) 1 journal December 2002
Contribution Purine Nucleotide Biosynthesis de novo to the Formation of Caffeine in Young Tea (Camellia sinensis) Leaves journal February 1999
Caffeine biosynthesis in young leaves of Camellia sinensis: In vitro studies on N-methyltransferase activity involved in the conversion of xanthosine to caffeine journal November 1996
Metabolism of Caffeine and Related Purine Alkaloids in Leaves of Tea (Camellia sinensis L.) journal January 1997
Biosynthesis of Caffeine in Leaves of Coffee journal July 1996
Purine and purine alkaloid metabolism in Camellia and Coffea plants journal August 1992
Purification and Characterization of Caffeine Synthase from Tea Leaves journal June 1999
Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme journal December 2005
Genes encoding ribonucleoside hydrolase 1 and 2 from Corynebacterium ammoniagenes journal April 2006

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