Quantifying Carbon-14 for Biology Using Cavity Ring-Down Spectroscopy

McCartt, A. Daniel; Ognibene, Ted J.; Bench, Graham; Turteltaub, Kenneth W.

doi:10.1021/acs.analchem.6b02054

Title: Quantifying Carbon-14 for Biology Using Cavity Ring-Down Spectroscopy

Journal Article · Tue Jul 26 00:00:00 EDT 2016 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.6b02054· OSTI ID:1367975

McCartt, A. Daniel ^[1]; Ognibene, Ted J. ^[1]; Bench, Graham ^[1]; Turteltaub, Kenneth W. ^[1]

Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

A cavity ring-down spectroscopy (CRDS) instrument was developed using mature, robust hardware for the measurement of carbon-14 in biological studies. The system was characterized using carbon-14 elevated glucose samples and returned a linear response up to 387 times contemporary carbon-14 concentrations. Carbon-14 free and contemporary carbon-14 samples with varying carbon-13 concentrations were used to assess the method detection limit of approximately one-third contemporary carbon-14 levels. Sources of inaccuracies are presented and discussed, and the capability to measure carbon-14 in biological samples is demonstrated by comparing pharmacokinetics from carbon-14 dosed guinea pigs analyzed by both CRDS and accelerator mass spectrometry. Here, the CRDS approach presented affords easy access to powerful carbon-14 tracer techniques that can characterize complex biochemical systems.

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Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1367975

Report Number(s):: LLNL-JRNL-693042

Journal Information:: Analytical Chemistry, Vol. 88, Issue 17; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 27 works

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