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Title: Design and characterization of hydrogel-based microfluidic devices with biomimetic solute transport networks

Authors:
 [1]; ORCiD logo [2]
  1. Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, Seoul 139-743, South Korea
  2. Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina 27695, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1361786
Grant/Contract Number:
08NT0001925
Resource Type:
Journal Article: Publisher's Accepted Manuscript
Journal Name:
Biomicrofluidics
Additional Journal Information:
Journal Volume: 11; Journal Issue: 2; Related Information: CHORUS Timestamp: 2018-02-14 21:45:37; Journal ID: ISSN 1932-1058
Publisher:
American Institute of Physics
Country of Publication:
United States
Language:
English

Citation Formats

Koo, Hyung-Jun, and Velev, Orlin D. Design and characterization of hydrogel-based microfluidic devices with biomimetic solute transport networks. United States: N. p., 2017. Web. doi:10.1063/1.4978617.
Koo, Hyung-Jun, & Velev, Orlin D. Design and characterization of hydrogel-based microfluidic devices with biomimetic solute transport networks. United States. doi:10.1063/1.4978617.
Koo, Hyung-Jun, and Velev, Orlin D. Wed . "Design and characterization of hydrogel-based microfluidic devices with biomimetic solute transport networks". United States. doi:10.1063/1.4978617.
@article{osti_1361786,
title = {Design and characterization of hydrogel-based microfluidic devices with biomimetic solute transport networks},
author = {Koo, Hyung-Jun and Velev, Orlin D.},
abstractNote = {},
doi = {10.1063/1.4978617},
journal = {Biomicrofluidics},
number = 2,
volume = 11,
place = {United States},
year = {Wed Mar 01 00:00:00 EST 2017},
month = {Wed Mar 01 00:00:00 EST 2017}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record at 10.1063/1.4978617

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  • A novel composite material consisting of calcium-deficient hydroxyapatite (CdHAP) biomimetically deposited in a bacterial cellulose hydrogel was synthesized and characterized. Cellulose produced by Gluconacetobacter hansenii was purified and sequentially incubated in solutions of calcium chloride followed by sodium phosphate dibasic. A substantial amount of apatite (50-90% of total dry weight) was homogeneously incorporated throughout the hydrogel after this treatment. X-ray diffractometry (XRD) showed that CdHAP crystallites had formed in the cellulose. XRD further demonstrated that the CdHAP was comprised of 10-50nm anisotropic crystallites elongated in the c-axis, similar to natural bone apatite. Fourier transform infrared (FTIR) spectroscopy demonstrated that hydroxylmore » IR bands of the cellulose shifted to lower wave numbers indicating that a coordinate bond had possibly formed between the CdHAP and the cellulose hydroxyl groups. FTIR also suggested that the CdHAP had formed from an octacalcium phosphate precursor similar to physiological bone. Scanning electron microscopy (SEM) images confirmed that uniform ?1 mm spherical CdHAP particles comprised of nanosized crystallites with a lamellar morphology had formed in the cellulose. The synthesis of the composite mimics the natural biomineralization of bone indicating that bacterial cellulose can be used as a template for biomimetic apatite formation. This composite may have potential use as an orthopedic biomaterial.« less