Repeat length variation in the dopamine D4 receptor gene shows no evidence of association with schizophrenia
Journal Article
·
· American Journal of Medical Genetics
- Univ. of Wales College of Medicine, Cardiff (United Kingdom); and others
The D4 receptor has been shown to exist in several allelic forms reflecting variation in the number of 48 base-pair sequence repeats in the putative cytoplasmic loop. We report a comparison of repeat length variation between schizophrenic patients and controls. Our sample of 106 unrelated schizophrenic cases and 119 controls showed no significant differences in allele or genotype distribution between patients and controls. In particular, we were unable to support the previous observation of an excess of 4-repeat homozygotes in patients. 16 refs., 2 tabs.
- Sponsoring Organization:
- USDOE
- OSTI ID:
- 135922
- Journal Information:
- American Journal of Medical Genetics, Journal Name: American Journal of Medical Genetics Journal Issue: 3 Vol. 54; ISSN 0148-7299; ISSN AJMGDA
- Country of Publication:
- United States
- Language:
- English
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