Cellular dosimetry: Absorbed fractions for monoenergetic electron and alpha particle sources and S-values for radionuclides uniformly distributed in different cell compartments

Journal Article · Tue Feb 01 04:00:00 EST 1994 · Journal of Nuclear Medicine Technology

OSTI ID:135837

Goddu, S M; Howell, R W; Rao, D V ^[1]

---

1. Univ. of Medicine and Denistry of New Jersey, Newark (United States)

The importance of cellular dosimetry in both diagnostic and therapeutic nuclear medicine is becoming increasingly recognized. Experimental range-energy relations for electrons and alpha particles, along with derived geometric reduction factors, are used to calculate cellular absorbed fractions for these radiations. The resulting absorbed fractions are employed to calculate cellular S-values for several radionuclides. Cellular absorbed fractions for monoenergetic electron sources with energies ranging from 0.1 keV to 1 MeV, distributed uniformly in the source region, are calculated for several target {l_arrow} source combinations including cell{l_arrow}cell, cell{l_arrow}cell surface, nucleus{l_arrow}nucleus, nucleus {l_arrow}cytoplasm and nucleus {l_arrow}cell surface. Similar data are also provided for monoenergetic alpha particle sources with energies ranging from 3 to 10 MeV. S-values are also conveniently tabulated for {sup 32}P, {sup 35}S, {sup 86}Rb, {sup 89}Sr, {sup 90}Y, {sup 91}Y {sup 114M}In, {sup 131}I, Auger electron-emitters {sup 51}Cr, {sup 67}Ga, {sup 99m}Tc, {sup 111}In, {sup 123}I, {sup 201}Tl, {sup 203}Pb and the alpha emitter {sup 210}Po. In addition, S-values are given for radionuclides in the {sup 212}Pb decay series, including {sup 212}Pb, {sup 212}Bi and {sup 212}Po. Both absorbed fractions and S-values are supplied for a number of different size cells and cell nuclei. With the absorbed fractions and S-values in hand, along with experimentally determined information on the biokinetics and subcellular distribution of the radionuclides, the cellular self-absorbed dose can be conveniently calculated. 33 refs., 2 figs., 17 tabs.

• OSTI ID: 135837
• Journal Information: Journal of Nuclear Medicine Technology, Journal Name: Journal of Nuclear Medicine Technology Journal Issue: 2 Vol. 35; ISSN JNMTB4; ISSN 0091-4916
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
ALPHA DOSIMETRY
ALPHA SOURCES
BISMUTH 212
CHROMIUM 51
ELECTRON DOSIMETRY
ELECTRON SOURCES
GALLIUM 67
INDIUM 111
INDIUM 114
IODINE 123
IODINE 131
LEAD 203
LEAD 212
PHOSPHORUS 32
POLONIUM 210
POLONIUM 212
RADIATION DOSES
RUBIDIUM 86
STRONTIUM 89
SUBCELLULAR DISTRIBUTION
SULFUR 35
TECHNETIUM 99
THALLIUM 201
YTTRIUM 90
YTTRIUM 91