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U.S. Department of Energy
Office of Scientific and Technical Information

Disposable world-to-chip interface for digital microfluidics

Patent ·
OSTI ID:1357556

The present disclosure sets forth incorporating microfluidic chips interfaces for use with digital microfluidic processes. Methods and devices according to the present disclosure utilize compact, integrated platforms that interface with a chip upstream and downstream of the reaction, as well as between intermediate reaction steps if needed. In some embodiments these interfaces are automated, including automation of a multiple reagent process. Various reagent delivery systems and methods are also disclosed.

Research Organization:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
SC0001249; SC0005056
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent Number(s):
9,649,632
Application Number:
14/406,195
OSTI ID:
1357556
Country of Publication:
United States
Language:
English

References (6)

Soft printing of droplets pre-metered by electrowetting journal September 2004
Design and Optimization of Coin-Shaped Microreactor Chips for PET Radiopharmaceutical Synthesis journal February 2010
Very high pressure HPLC with 1 mm id columns journal April 2004
Milliliter-to-microliter platform for on-demand loading of aqueous and non-aqueous droplets to digital microfluidics conference June 2011
Microchip HPLC of Peptides and Proteins journal May 2005
Dried Blood Spot Analysis by Digital Microfluidics Coupled to Nanoelectrospray Ionization Mass Spectrometry journal March 2012

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