Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia

Schroeder, Frederick A.; Gilbert, Tonya M.; Feng, Ningping; Taillon, Brendan D.; Volkow, Nora D.; Innis, Robert B.; Hooker, Jacob M.; Lipska, Barbara K.

doi:10.1021/acschemneuro.6b00372

Title: Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia

Journal Article · Tue Dec 13 00:00:00 EST 2016 · ACS Chemical Neuroscience

DOI:https://doi.org/10.1021/acschemneuro.6b00372· OSTI ID:1357307

; Gilbert, Tonya M.; Feng, Ningping; Taillon, Brendan D.; Volkow, Nora D.; Innis, Robert B.; Hooker, Jacob M.; Lipska, Barbara K.

Postmortem brain studies support dysregulated expression of the histone deacetylase enzymes, HDAC1 and HDAC2, as a central feature in diseases including schizophrenia, bipolar disorder, and depression.

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Research Organization:: Brigham and Women's Hospital (Harvard Medical School), Boston, MA (United States). Massachusetts General Hospital

Sponsoring Organization:: USDOE

Grant/Contract Number:: SC0008430

OSTI ID:: 1357307

Alternate ID(s):: OSTI ID: 1426181

Journal Information:: ACS Chemical Neuroscience, Journal Name: ACS Chemical Neuroscience Vol. 8 Journal Issue: 3; ISSN 1948-7193

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 31 works

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References (37)

Subcortical structure alterations impact language processing in individuals with schizophrenia and those at high genetic risk Li, Xiaobo; Black, Margaret; Xia, Shugao Schizophrenia Research, Vol. 169, Issue 1-3 https://doi.org/10.1016/j.schres.2015.08.001	journal	December 2015
Promoter Decommissioning by the NuRD Chromatin Remodeling Complex Triggers Synaptic Connectivity in the Mammalian Brain Yamada, Tomoko; Yang, Yue; Hemberg, Martin Neuron, Vol. 83, Issue 1 https://doi.org/10.1016/j.neuron.2014.05.039	journal	July 2014
HDAC2 negatively regulates memory formation and synaptic plasticity Guan, Ji-Song; Haggarty, Stephen J.; Giacometti, Emanuela Nature, Vol. 459, Issue 7243 https://doi.org/10.1038/nature07925	journal	May 2009
Epigenetic Basis of Mental Illness Nestler, Eric J.; Peña, Catherine J.; Kundakovic, Marija The Neuroscientist, Vol. 22, Issue 5 https://doi.org/10.1177/1073858415608147	journal	July 2016
In Vivo Imaging of Histone Deacetylases (HDACs) in the Central Nervous System and Major Peripheral Organs Wang, Changning; Schroeder, Frederick A.; Wey, Hsiao-Ying Journal of Medicinal Chemistry, Vol. 57, Issue 19 https://doi.org/10.1021/jm500872p	journal	September 2014
Molecular profiles of schizophrenia in the CNS at different stages of illness Narayan, Sujatha; Tang, Bin; Head, Steven R. Brain Research, Vol. 1239 https://doi.org/10.1016/j.brainres.2008.08.023	journal	November 2008
Searching human brain for mechanisms of psychiatric disorders. Implications for studies on schizophrenia Berretta, Sabina; Heckers, Stephan; Benes, Francine M. Schizophrenia Research, Vol. 167, Issue 1-3 https://doi.org/10.1016/j.schres.2014.10.019	journal	September 2015
A Selective HDAC 1/2 Inhibitor Modulates Chromatin and Gene Expression in Brain and Alters Mouse Behavior in Two Mood-Related Tests Schroeder, Frederick A.; Lewis, Michael C.; Fass, Daniel M. PLoS ONE, Vol. 8, Issue 8 https://doi.org/10.1371/journal.pone.0071323	journal	August 2013
Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development MacDonald, Jessica L.; Roskams, A. Jane Developmental Dynamics, Vol. 237, Issue 8 https://doi.org/10.1002/dvdy.21626	journal	August 2008
Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain Anderson, Kyle W.; Chen, Junjun; Wang, Meiyao PLOS ONE, Vol. 10, Issue 5 https://doi.org/10.1371/journal.pone.0126592	journal	May 2015
Partitioning heritability by functional annotation using genome-wide association summary statistics Finucane, Hilary K.; Bulik-Sullivan, Brendan; Gusev, Alexander Nature Genetics, Vol. 47, Issue 11 https://doi.org/10.1038/ng.3404	journal	September 2015
Antidepressant action of HDAC inhibition in the prefrontal cortex Covington, H. E.; Maze, I.; Vialou, V. Neuroscience, Vol. 298 https://doi.org/10.1016/j.neuroscience.2015.04.030	journal	July 2015
Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system Koussounadis, Antonis; Langdon, Simon P.; Um, In Hwa Scientific Reports, Vol. 5, Issue 1 https://doi.org/10.1038/srep10775	journal	June 2015
Grey matter morphological anomalies in the caudate head in first-episode psychosis patients with delusions of reference Tao, Haojuan; Wong, Gloria H. Y.; Zhang, Huiran Psychiatry Research: Neuroimaging, Vol. 233, Issue 1 https://doi.org/10.1016/j.pscychresns.2015.04.011	journal	July 2015
Transcriptomic evidence for immaturity of the prefrontal cortex in patients with schizophrenia Hagihara, Hideo; Ohira, Koji; Takao, Keizo Molecular Brain, Vol. 7, Issue 1 https://doi.org/10.1186/1756-6606-7-41	journal	January 2014
Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition Covington, Herbert E.; Vialou, Vincent F.; LaPlant, Quincey Neuroscience Letters, Vol. 493, Issue 3 https://doi.org/10.1016/j.neulet.2011.02.022	journal	April 2011
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice Peleg, S.; Sananbenesi, F.; Zovoilis, A. Science, Vol. 328, Issue 5979 https://doi.org/10.1126/science.1186088	journal	May 2010
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes Vandesompele, Jo; De Preter, Katleen; Pattyn, Filip Genome Biology, Vol. 3, Issue 7 https://doi.org/10.1186/gb-2002-3-7-research0034	journal	June 2002
Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance Strebl, Martin G.; Wang, Changning; Schroeder, Frederick A. ACS Chemical Neuroscience, Vol. 7, Issue 5 https://doi.org/10.1021/acschemneuro.5b00297	journal	December 2015
An epigenetic blockade of cognitive functions in the neurodegenerating brain Gräff, Johannes; Rei, Damien; Guan, Ji-Song Nature, Vol. 483, Issue 7388 https://doi.org/10.1038/nature10849	journal	February 2012
Temporal dynamics and genetic control of transcription in the human prefrontal cortex Colantuoni, Carlo; Lipska, Barbara K.; Ye, Tianzhang Nature, Vol. 478, Issue 7370 https://doi.org/10.1038/nature10524	journal	October 2011
Prefrontal Cortical Dysfunction After Overexpression of Histone Deacetylase 1 Jakovcevski, Mira; Bharadwaj, Rahul; Straubhaar, Juerg Biological Psychiatry, Vol. 74, Issue 9 https://doi.org/10.1016/j.biopsych.2013.03.020	journal	November 2013
Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities Madison, J. M.; Zhou, F.; Nigam, A. Molecular Psychiatry, Vol. 20, Issue 6 https://doi.org/10.1038/mp.2015.7	journal	March 2015
Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars Benes, F. M.; Lim, B.; Matzilevich, D. Proceedings of the National Academy of Sciences, Vol. 104, Issue 24 https://doi.org/10.1073/pnas.0703806104	journal	June 2007
Histone deacetylases 1 and 2 control the progression of neural precursors to neurons during brain development Montgomery, R. L.; Hsieh, J.; Barbosa, A. C. Proceedings of the National Academy of Sciences, Vol. 106, Issue 19 https://doi.org/10.1073/pnas.0902750106	journal	April 2009
Histone deactylase 1 expression is increased in the prefrontal cortex of schizophrenia subjects: Analysis of the National Brain Databank microarray collection Sharma, Rajiv P.; Grayson, Dennis R.; Gavin, David P. Schizophrenia Research, Vol. 98, Issue 1-3 https://doi.org/10.1016/j.schres.2007.09.020	journal	January 2008
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity Kurita, Mitsumasa; Holloway, Terrell; García-Bea, Aintzane Nature Neuroscience, Vol. 15, Issue 9 https://doi.org/10.1038/nn.3181	journal	August 2012
Disease- and age-related changes in histone acetylation at gene promoters in psychiatric disorders Tang, B.; Dean, B.; Thomas, E. A. Translational Psychiatry, Vol. 1, Issue 12 https://doi.org/10.1038/tp.2011.61	journal	December 2011
CHRNA7 and CHRFAM7A mRNAs: Co-Localized and Their Expression Levels Altered in the Postmortem Dorsolateral Prefrontal Cortex in Major Psychiatric Disorders Kunii, Yasuto; Zhang, Wenyu; Xu, Qing American Journal of Psychiatry, Vol. 172, Issue 11 https://doi.org/10.1176/appi.ajp.2015.14080978	journal	November 2015
Insights into neuroepigenetics through human histone deacetylase PET imaging Wey, Hsiao-Ying; Gilbert, Tonya M.; Zürcher, Nicole R. Science Translational Medicine, Vol. 8, Issue 351 https://doi.org/10.1126/scitranslmed.aaf7551	journal	August 2016
Abnormalities in Hemispheric Specialization of Caudate Nucleus Connectivity in Schizophrenia Mueller, Sophia; Wang, Danhong; Pan, Ruiqi JAMA Psychiatry, Vol. 72, Issue 6 https://doi.org/10.1001/jamapsychiatry.2014.3176	journal	June 2015
Antidepressants and mood stabilizers effects on histone deacetylase expression in C57BL/6 mice: Brain region specific changes Ookubo, Masanori; Kanai, Hirohiko; Aoki, Harusuke Journal of Psychiatric Research, Vol. 47, Issue 9 https://doi.org/10.1016/j.jpsychires.2013.05.028	journal	September 2013
LSD1 Neurospecific Alternative Splicing Controls Neuronal Excitability in Mouse Models of Epilepsy Rusconi, Francesco; Paganini, Leda; Braida, Daniela Cerebral Cortex, Vol. 25, Issue 9 https://doi.org/10.1093/cercor/bhu070	journal	April 2014
Critical Factors in Gene Expression in Postmortem Human Brain: Focus on Studies in Schizophrenia Lipska, Barbara K.; Deep-Soboslay, Amy; Weickert, Cynthia Shannon Biological Psychiatry, Vol. 60, Issue 6 https://doi.org/10.1016/j.biopsych.2006.06.019	journal	September 2006
Age-related changes in the expression of schizophrenia susceptibility genes in the human prefrontal cortex Colantuoni, Carlo; Hyde, Thomas M.; Mitkus, Shruti Brain Structure and Function, Vol. 213, Issue 1-2 https://doi.org/10.1007/s00429-008-0181-5	journal	May 2008
PET Imaging Demonstrates Histone Deacetylase Target Engagement and Clarifies Brain Penetrance of Known and Novel Small Molecule Inhibitors in Rat Schroeder, F. A.; Wang, C.; Van de Bittner, G. C. ACS Chemical Neuroscience, Vol. 5, Issue 10 https://doi.org/10.1021/cn500162j	journal	September 2014
Kinetic Analysis and Quantification of [ ¹¹ C]Martinostat for in Vivo HDAC Imaging of the Brain Wey, Hsiao-Ying; Wang, Changning; Schroeder, Frederick A. ACS Chemical Neuroscience, Vol. 6, Issue 5 https://doi.org/10.1021/acschemneuro.5b00066	journal	March 2015

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Title: Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia

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