Selective Inhibition of c-Myc/Max Dimerization by a Pyrazolo[1,5-a]pyrimidine
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May 2007
Transcriptional activation by Myc is under negative control by the transcription factor AP-2.
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April 1995
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
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January 2005
Metadynamics: Metadynamics
Barducci, Alessandro; Bonomi, Massimiliano; Parrinello, Michele
Wiley Interdisciplinary Reviews: Computational Molecular Science, Vol. 1, Issue 5
https://doi.org/10.1002/wcms.31
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February 2011
DNA-Dependent Protein Kinase Inhibitor (OK-1035) Suppresses p21 Expression in HCT116 Cells Containing Wild-Type p53 Induced by Adriamycin
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April 1996
The atomic structure of protein-protein recognition sites 1 1Edited by A. R. Fersht
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February 1999
Structure, function, and dynamics of the dimerization and DNA-binding domain of oncogenic transcription factor v-Myc11Edited by P. E. Wright
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April 2001
Tyrosine Kinase Targeted Treatment of Chronic Myelogenous Leukemia and Other Myeloproliferative Neoplasms
book
November 2012
Tumor microenvironment: becoming sick of Myc
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October 2011
Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice
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May 2008
The FT210 cell line is a mouse G2 phase mutant with a temperature-sensitive CDC2 gene product
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October 1990
Mechanism of specificity in the Fos-Jun oncoprotein heterodimer
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February 1992
BRD4 Bromodomain Gene Rearrangement in Aggressive Carcinoma with Translocation t(15;19)
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December 2001
The many faces of c-MYC
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August 2003
mRNA expression profiles for the response of human tumor cell lines to the antimalarial drugs artesunate, arteether, and artemether
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August 2002
Bromodomain: an acetyl-lysine binding domain
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January 2002
Intrinsic Disorder in Cell-signaling and Cancer-associated Proteins
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October 2002
Mnt Takes Control as Key Regulator of the Myc/Max/Mxd Network
book
January 2007
Involvement of the TIP60 Histone Acetylase Complex in DNA Repair and Apoptosis
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August 2000
X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA
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January 2003
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
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March 2001
Extended disordered proteins: targeting function with less scaffold
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February 2003
Transcription elongation factors DSIF and NELF: Promoter-proximal pausing and beyond
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January 2013
Six lysine residues on c-Myc are direct substrates for acetylation by p300
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October 2005
Hsa-let-7a functions as a tumor suppressor in renal cell carcinoma cell lines by targeting c-myc
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January 2012
Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells
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July 2010
A credit-card library approach for disrupting protein–protein interactions
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April 2006
Small-molecule perturbation of competing interactions between c-Myc and Max
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February 2009
Small molecule inhibitors of Myc/Max dimerization and Myc-induced cell transformation
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November 2009
Pharmacophore identification of c-Myc inhibitor 10074-G5
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January 2013
Inhibition of transcription factors with small organic molecules
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August 2008
A complex task? Direct modulation of transcription factors with small molecules
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June 2010
Intrinsically disordered proteins are potential drug targets
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August 2010
Distinct Thresholds Govern Myc's Biological Output In Vivo
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December 2008
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
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March 2012
Recent highlights of RNA-polymerase-II-mediated transcription
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June 2004
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factors
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June 2005
The multi-tasking P-TEFb complex
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June 2008
c-Myc Regulates Transcriptional Pause Release
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April 2010
Hallmarks of Cancer: The Next Generation
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March 2011
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
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September 2011
Transcriptional Amplification in Tumor Cells with Elevated c-Myc
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September 2012
c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells
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September 2012
Selective Inhibition of c-Myc/Max Dimerization and DNA Binding by Small Molecules
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July 2006
Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules
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November 2008
Targeted therapy in melanoma
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March 2013
Cell cycle kinases in cancer
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February 2007
The Bromodomain Protein Brd4 Is a Positive Regulatory Component of P-TEFb and Stimulates RNA Polymerase II-Dependent Transcription
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August 2005
Recruitment of P-TEFb for Stimulation of Transcriptional Elongation by the Bromodomain Protein Brd4
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August 2005
Function and structure of inherently disordered proteins
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December 2008
Evolution and disorder
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June 2011
Conditional transgenic models define how MYC initiates and maintains tumorigenesis
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August 2006
Mechanism of transcriptional activation by the Myc oncoproteins
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August 2006
Rational drug design via intrinsically disordered protein
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October 2006
Cell division control by the Chromosomal Passenger Complex
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July 2012
The leucine zippers of the HLH-LZ proteins Max and c-Myc preferentially form heterodimers
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October 1995
Thermodynamic characterization of the structural stability of the coiled-coil region of the bZIP transcription factor GCN4
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June 1993
The dimerization stability of the HLH-LZ transcription protein family is modulated by the leucine zippers: A CD and NMR study of TFEB and c-Myc
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September 1994
Assembly of b/HLH/z Proteins c-Myc, Max, and Mad1 with Cognate DNA: Importance of Protein−Protein and Protein−DNA Interactions †
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September 2005
Protein−Protein Interactions: Interface Structure, Binding Thermodynamics, and Mutational Analysis
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August 1997
Small-Molecule Inhibition of c-MYC:MAX Leucine Zipper Formation Is Revealed by Ion Mobility Mass Spectrometry
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November 2012
Multiple Independent Binding Sites for Small-Molecule Inhibitors on the Oncoprotein c-Myc
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June 2009
Progress in the Development and Application of Small Molecule Inhibitors of Bromodomain–Acetyl-lysine Interactions
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September 2012
A Bias-Exchange Approach to Protein Folding
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May 2007
Inactivation of Myc-induced p53-dependent apoptosis in human tumors
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January 2001
An extensive network of coupling among gene expression machines
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April 2002
Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma
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April 2011
Active genes are tri-methylated at K4 of histone H3
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September 2002
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
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October 2004
A high-resolution map of active promoters in the human genome
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June 2005
Modelling Myc inhibition as a cancer therapy
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August 2008
The landscape of somatic copy-number alteration across human cancers
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February 2010
Selective inhibition of BET bromodomains
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September 2010
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
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August 2011
Myc-binding-site recognition in the human genome is determined by chromatin context
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June 2006
Point mutations in the c–Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas
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September 1993
Tumor cell-specific bioluminescence platform to identify stroma-induced changes to anticancer drug activity
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March 2010
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
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May 1996
Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
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June 2007
The Concept of Synthetic Lethality in the Context of Anticancer Therapy
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August 2005
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
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August 2007
FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation
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February 2008
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
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April 2004
Intrinsically unstructured proteins and their functions
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March 2005
C-MYC overexpression is required for continuous suppression of oncogene-induced senescence in melanoma cells
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August 2008
Myc influences global chromatin structure
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May 2006
Stimulation of c‐MYC transcriptional activity and acetylation by recruitment of the cofactor CBP
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April 2003
C-myc overexpression and p53 loss cooperate to promote genomic instability
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February 1999
MYC oncogenes and human neoplastic disease
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May 1999
Low molecular weight inhibitors of Myc–Max interaction and function
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September 2003
Opposite long-term regulation of c-Myc and p27Kip1 through overactivation of Raf-1 and the MEK/ERK module in proliferating human choroidal melanoma cells
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December 2003
c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle
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October 2007
Small-molecule inhibitors of dimeric transcription factors: Antagonism of protein–protein and protein–DNA interactions
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January 2012
Max is acetylated by p300 at several nuclear localization residues
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April 2007
Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes
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August 2013
Mechanisms of small-molecule binding to intrinsically disordered proteins
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September 2012
A TRAIL receptor-dependent synthetic lethal relationship between MYC activation and GSK3 /FBW7 loss of function
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October 2005
Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation
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April 2006
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts
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March 2002
Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
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July 2007
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
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November 2008
Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase
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July 2010
Stem cell-like micro-RNA signature driven by Myc in aggressive liver cancer
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November 2010
Targeting MYC dependence in cancer by inhibiting BET bromodomains
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September 2011
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
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June 2013
Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
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June 2001
Regulation of apoptosis at cell division by p34cdc2 phosphorylation of survivin
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November 2000
Binding in the growth hormone receptor complex.
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January 1996
Principles of protein-protein interactions.
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January 1996
Diverse karyotypic abnormalities of the c-myc locus associated with c-myc dysregulation and tumor progression in multiple myeloma
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January 2000
Purification of P-TEFb, a Transcription Factor Required for the Transition into Productive Elongation
journal
May 1995
Mapping Part of the Functional Epitope for Ligand Binding on the Receptor for Urokinase-type Plasminogen Activator by Site-directed Mutagenesis
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December 1999
Two-pronged Binding with Bromodomain-containing Protein 4 Liberates Positive Transcription Elongation Factor b from Inactive Ribonucleoprotein Complexes
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November 2011
Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter
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October 2002
The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation
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February 2007
Targeted expression of MYCN causes neuroblastoma in transgenic mice
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June 1997
IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases
journal
April 1998
Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif
journal
December 1999
DNA Binding of Jun and Fos bZip Domains: Homodimers and Heterodimers Induce a DNA Conformational Change in Solution
journal
November 1996
Poly(ADP-Ribose) Polymerase Inhibitors in Triple-Negative Breast Cancer
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January 2010
c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression
journal
October 2002
The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote
journal
June 2004
Identification of multiple cyclin subunits of human P-TEFb
journal
March 1998
The Myc-dependent angiogenic switch in tumors is mediated by interleukin 1beta
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September 2006
The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth
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March 2007
Endogenous Myc maintains the tumor microenvironment
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April 2011
Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
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March 2013
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability
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October 2000
Binding of c-Myc to chromatin mediates mitogen-induced acetylation of histone H4 and gene activation
journal
August 2001
The potential role of Aurora kinase inhibitors in haematological malignancies: Review
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October 2011
In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization
journal
August 2010
Stabilizers of the Max Homodimer Identified in Virtual Ligand Screening Inhibit Myc Function
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June 2009
Sustained Loss of a Neoplastic Phenotype by Brief Inactivation of MYC
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July 2002
CANCER: Enhanced: Addiction to Oncogenes--the Achilles Heal of Cancer
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July 2002
Divergent Transcription from Active Promoters
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December 2008
A SUMOylation-Dependent Transcriptional Subprogram Is Required for Myc-Driven Tumorigenesis
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December 2011
Cancer Genome Landscapes
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March 2013
Potential of the Synthetic Lethality Principle
journal
November 2013
A hot spot of binding energy in a hormone-receptor interface
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January 1995
Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1
journal
September 2007
Brd4 Recruits P-TEFb to Chromosomes at Late Mitosis To Promote G1 Gene Expression and Cell Cycle Progression
journal
November 2007
BRD4 Coordinates Recruitment of Pause Release Factor P-TEFb and the Pausing Complex NELF/DSIF To Regulate Transcription Elongation of Interferon-Stimulated Genes
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April 2013
The Brd4 Extraterminal Domain Confers Transcription Activation Independent of pTEFb by Recruiting Multiple Proteins, Including NSD3
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May 2011
The nerve growth factor-responsive PC12 cell line does not express the Myc dimerization partner Max.
journal
July 1995
Conformational changes induced in Hoxb-8/Pbx-1 heterodimers in solution and upon interaction with specific DNA.
journal
September 1997
PER and TIM Inhibit the DNA Binding Activity of aDrosophila CLOCK-CYC/dBMAL1 Heterodimer without Disrupting Formation of the Heterodimer: a Basis for Circadian Transcription
journal
August 1999
The Max Network Gone Mad
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February 2001
The c-MYC Oncoprotein Is a Substrate of the Acetyltransferases hGCN5/PCAF and TIP60
journal
December 2004
Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis
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July 2005
Formation of an Active Tissue-Specific Chromatin Domain Initiated by Epigenetic Marking at the Embryonic Stem Cell Stage
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March 2005
Origins of Specificity in Protein-DNA Recognition
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June 2010
Intrinsically Disordered Proteins in Human Diseases: Introducing the D 2 Concept
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June 2008
MicroRNA Let-7a Down-regulates MYC and Reverts MYC-Induced Growth in Burkitt Lymphoma Cells
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October 2007
BRD4 Sustains Melanoma Proliferation and Represents a New Target for Epigenetic Therapy
journal
August 2013
Improved low molecular weight Myc-Max inhibitors
journal
September 2007
BH3 Mimetics: Status of the Field and New Developments
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August 2013
Cancer-Associated Fibroblasts Drive the Progression of Metastasis through both Paracrine and Mechanical Pressure on Cancer Tissue
journal
September 2012
Molecular pathogenesis and clinical management of Fanconi anemia
journal
November 2012
CXCR4 downregulation of let-7a drives chemoresistance in acute myeloid leukemia
journal
May 2013
Therapeutic Targeting of Myc
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June 2010
Myc Roles in Hematopoiesis and Leukemia
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June 2010
MYC and Breast Cancer
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June 2010
Transcriptional Repression: The Dark Side of Myc
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June 2010
MYC and Prostate Cancer
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June 2010
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology
journal
January 2012
Addiction to c-MYC in multiple myeloma
journal
September 2012
Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group Study
journal
April 2012
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
journal
October 2012
c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover
journal
March 2000
Mechanisms of Action of and Resistance to Antitubulin Agents: Microtubule Dynamics, Drug Transport, and Cell Death
journal
March 1999
c-myc in the hematopoietic lineage is crucial for its angiogenic function in the mouse embryo
journal
July 2008
let-7 MicroRNA Functions as a Potential Growth Suppressor in Human Colon Cancer Cells
journal
January 2006
B-RAF and N-RAS Mutations Are Preserved during Short Time In Vitro Propagation and Differentially Impact Prognosis
journal
February 2007
Mitochondrial Structure, Function and Dynamics Are Temporally Controlled by c-Myc
journal
May 2012
The Impact of Small Molecule Binding on the Energy Landscape of the Intrinsically Disordered Protein C-Myc
journal
July 2012
In Vivo Inhibition of c-MYC in Myeloid Cells Impairs Tumor-Associated Macrophage Maturation and Pro-Tumoral Activities
journal
September 2012
Small-molecule inhibitors of the p53-HDM2 interaction for the treatment of cancer
journal
November 2008
Intrinsic Disorder and Functional Proteomics
journal
March 2007
Inhibitors of Cell Cycle Kinases: Recent Advances and Future Prospects as Cancer Therapeutics
journal
January 2012
Disruption of Myc-Max Heterodimerization with Improved Cell-Penetrating Analogs of the Small Molecule 10074-G5
journal
June 2013
Discovery of Modulators of Protein-Protein Interactions: Current Approaches and Limitations
journal
February 2011
Tumor microenvironment and angiogenesis
journal
January 2008
Recapitulating the α-helix: nonpeptidic, low-molecular-weight ligands for the modulation of helix-mediated protein–protein interactions
journal
December 2013
Stromal Fibroblasts in Cancer: A Novel Tumor-Promoting Cell Type
journal
July 2006
The Function and Regulation of the JARID1 Family of Histone H3 Lysine 4 Demethylases: the Myc Connection
journal
June 2007
P-TEFb is a Crucial Co-Factor for Myc Transactivation
journal
August 2007
The tumor suppressor p53: Cancer and aging
journal
April 2008
MYC, microRNAs and glutamine addiction in cancers
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October 2009
Insights into the function of the human P-TEFb component CDK9 in the regulation of chromatin modifications and co-transcriptional mRNA processing
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November 2009
CYCLINg through transcription: Post-translational modifications of P-TEFb regulate transcription elongation
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May 2010
P-TEFb stimulates transcription elongation and pre-mRNA splicing through multilateral mechanisms
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March 2010