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Title: Apolipoprotein nanodiscs with telodendrimer

Abstract

The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.

Inventors:
; ; ; ; ; ;
Publication Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1356293
Patent Number(s):
9,644,038
Application Number:
13/719,785
Assignee:
The Regents of the University of California LLNL
DOE Contract Number:
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Dec 19
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, and Xing, Li. Apolipoprotein nanodiscs with telodendrimer. United States: N. p., 2017. Web.
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, & Xing, Li. Apolipoprotein nanodiscs with telodendrimer. United States.
Luo, Juntao, He, Wei, Lam, Kit S., Henderson, Paul, Coleman, Matthew, Cheng, R. Holland, and Xing, Li. Tue . "Apolipoprotein nanodiscs with telodendrimer". United States. doi:. https://www.osti.gov/servlets/purl/1356293.
@article{osti_1356293,
title = {Apolipoprotein nanodiscs with telodendrimer},
author = {Luo, Juntao and He, Wei and Lam, Kit S. and Henderson, Paul and Coleman, Matthew and Cheng, R. Holland and Xing, Li},
abstractNote = {The present invention provides a nanodisc with a membrane scaffold protein. The nanodisc includes a membrane scaffold protein, a telodendrimer and a lipid. The membrane scaffold protein can be apolipoprotein. The telodendrimer has the general formula PEG-L-D-(R).sub.n, wherein D is a dendritic polymer; L is a bond or a linker linked to the focal point group of the dendritic polymer; each PEG is a poly(ethylene glycol) polymer; each R is and end group of the dendritic polymer, or and end group with a covalently bound hydrophobic group, hydrophilic group, amphiphilic compound, or drug; and subscript n is an integer from 2 to 20. Cell free methods of making the nanodiscs are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 09 00:00:00 EDT 2017},
month = {Tue May 09 00:00:00 EDT 2017}
}

Patent:

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