Male breast cancer incidence and mortality risk in the Japanese atomic bomb survivors – Differences in excess relative and absolute risk from female breast cancer

Journal Article · Fri Jun 10 00:00:00 EDT 2016 · Environmental Health Perspectives

DOI:https://doi.org/10.1289/EHP151· OSTI ID:1356160

Little, Mark P. ^[1]; McElvenny, Damien M. ^[2]

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1. National Inst. of Health, Rockville, MD (United States). National Cancer Inst. Division of Cancer Epidemiology and Genetics. Radiation Epidemiology Branch; National Institutes of Health
2. Inst. of Occupational Medicine, Edinburgh, Scotland (United Kingdom)

There are well-known associations of ionizing radiation with female breast cancer, and emerging evidence also for male breast cancer. In the UK, female breast cancer following occupational radiation exposure is among that set of cancers eligible for state compensation and consideration is currently being given to an extension to include male breast cancer. The objectives here, compare radiation-associated excess relative and absolute risks of male and female breast cancers. Breast cancer incidence and mortality data in the Japanese atomic-bomb survivors were analyzed using relative and absolute risk models via Poisson regression. As a result, we observed significant ( p≤ 0.01) dose-related excess risk for male breast cancer incidence and mortality. For incidence and mortality data, there are approximate 15-fold and 5- fold elevations, respectively, of relative risk for male compared with female breast cancer incidence, the former borderline significant (p = 0.050). In contrast, for incidence and mortality data there are approximate 20-fold and 10-fold elevations, respectively, of female absolute risk compared with male, both statistically significant (p < 0.001). There are no indications of differences between the sexes in age/time-since-exposure/age-at-exposure modifications to the relative or absolute excess risk. The probability of causation of male breast cancer following radiation exposure exceeds by at least 5-fold that of many other malignancies. In conclusion, there is evidence of much higher radiation-associated relative risk for male than for female breast cancer, although absolute excess risks for males are much less than for females. However, the small number of male cases and deaths suggests a degree of caution in interpretation of this finding.

• Research Organization: National Inst. of Health, Rockville, MD (United States)
• Sponsoring Organization: Ministry of Health, Labour, and Welfare (MHLW) (Japan); National Inst. of Health (NIH) (United States); USDOE; USDOE Office of Science (SC)
• Contributing Organization: Inst. of Occupational Medicine, Edinburgh, Scotland (United Kingdom)
• Grant/Contract Number: HS0000031; SC0000031
• OSTI ID: 1356160
• Alternate ID(s): OSTI ID: 1358436
• Journal Information: Environmental Health Perspectives, Journal Name: Environmental Health Perspectives Journal Issue: 2 Vol. 125; ISSN 0091-6765
• Publisher: National Institute of Environmental Health Sciences
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE