Knowns and unknowns in metabolomics identified by multidimensional NMR and hybrid MS/NMR methods
Metabolomics continues to make rapid progress through the development of new and better methods and their applications to gain insight into the metabolism of a wide range of different biological systems from a systems biology perspective. Customization of NMR databases and search tools allows the faster and more accurate identification of known metabolites, whereas the identification of unknowns, without a need for extensive purification, requires new strategies to integrate NMR with mass spectrometry, cheminformatics, and computational methods. For some applications, the use of covalent and non-covalent attachments in the form of labeled tags or nanoparticles can significantly reduce the complexity of these tasks.
- Research Organization:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (US)
- Sponsoring Organization:
- USDOE
- DOE Contract Number:
- AC05-76RL01830
- OSTI ID:
- 1353309
- Report Number(s):
- PNNL-SA-119034
- Journal Information:
- Current Opinion in Biotechnology, Journal Name: Current Opinion in Biotechnology Vol. 43; ISSN 0958-1669
- Publisher:
- Elsevier
- Country of Publication:
- United States
- Language:
- English
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