ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments

Chavali, Balagopalakrishna; Masquelin, Thierry; Nilges, Mark J.; Timm, David E.; Stout, Stephanie L.; Matter, William F.; Jin, Najia; Jadhav, Prabhakar K.; Deng, Gary G.

doi:10.1007/s00723-015-0698-8

Title: ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments

Journal Article · Tue May 19 00:00:00 EDT 2015 · Applied Magnetic Resonance

DOI:https://doi.org/10.1007/s00723-015-0698-8· OSTI ID:1352211

Chavali, Balagopalakrishna; Masquelin, Thierry; Nilges, Mark J.; Timm, David E.; Stout, Stephanie L.; Matter, William F.; Jin, Najia; Jadhav, Prabhakar K.; Deng, Gary G.

Cite

Export

Save

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: INDUSTRY

OSTI ID:: 1352211

Journal Information:: Applied Magnetic Resonance, Vol. 46, Issue 8; ISSN 0937-9347

Country of Publication:: United States

Language:: ENGLISH

References (32)

2.3 Å Resolution X-ray Crystal Structure of the Bisubstrate Analogue Inhibitor Salicylhydroxamic Acid Bound to Human Myeloperoxidase: A Model for a Prereaction Complex with Hydrogen Peroxide^, Davey, Curt A.; Fenna, Roger E. Biochemistry, Vol. 35, Issue 33 https://doi.org/10.1021/bi960577m	journal	January 1996
Anti-inflammatory Agents: Present and Future Dinarello, Charles A. Cell, Vol. 140, Issue 6 https://doi.org/10.1016/j.cell.2010.02.043	journal	March 2010
An EPR study of the peroxyl radicals induced by hydrogen peroxide in the haem proteins Svistunenko, Dimitri A. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1546, Issue 2 https://doi.org/10.1016/s0167-4838(01)00157-1	journal	April 2001
X-ray Crystal Structure and Characterization of Halide-binding Sites of Human Myeloperoxidase at 1.8 Å Resolution Fiedler, Tristan J.; Davey, Curt A.; Fenna, Roger E. Journal of Biological Chemistry, Vol. 275, Issue 16 https://doi.org/10.1074/jbc.275.16.11964	journal	April 2000
Comparative Study of Tyrosine Radicals in Hemoglobin and Myoglobins Treated with Hydrogen Peroxide Svistunenko, Dimitri A.; Dunne, Jacqueline; Fryer, Michael Biophysical Journal, Vol. 83, Issue 5 https://doi.org/10.1016/s0006-3495(02)75293-4	journal	November 2002
2-Thioxanthines Are Mechanism-based Inactivators of Myeloperoxidase That Block Oxidative Stress during Inflammation Tidén, Anna-Karin; Sjögren, Tove; Svensson, Mats Journal of Biological Chemistry, Vol. 286, Issue 43 https://doi.org/10.1074/jbc.m111.266981	journal	October 2011
Antioxidant activity applying an improved ABTS radical cation decolorization assay Re, Roberta; Pellegrini, Nicoletta; Proteggente, Anna Free Radical Biology and Medicine, Vol. 26, Issue 9-10 https://doi.org/10.1016/s0891-5849(98)00315-3	journal	May 1999
3-Chlorotyrosine as a Marker of Protein Damage by Myeloperoxidase in Tracheal Aspirates From Preterm Infants: Association With Adverse Respiratory Outcome Buss, I. Hendrikje; Senthilmohan, Revathy; Darlow, Brian A. Pediatric Research, Vol. 53, Issue 3 https://doi.org/10.1203/01.pdr.0000050655.25689.ce	journal	March 2003
Reassessment of the microbicidal activity of reactive oxygen species and hypochlorous acid with reference to the phagocytic vacuole of the neutrophil granulocyte Reeves, Emer P.; Nagl, Markus; Godovac-Zimmermann, Jasminca Journal of Medical Microbiology, Vol. 52, Issue 8 https://doi.org/10.1099/jmm.0.05181-0	journal	August 2003
Human Myeloperoxidase: Structure of a Cyanide Complex and Its Interaction with Bromide and Thiocyanate Substrates at 1.9 Å Resolution Blair-Johnson, Merilyn; Fiedler, Tristan; Fenna, Roger Biochemistry, Vol. 40, Issue 46 https://doi.org/10.1021/bi0111808	journal	October 2001
Neutrophils and immunity: challenges and opportunities Nathan, Carl Nature Reviews Immunology, Vol. 6, Issue 3 https://doi.org/10.1038/nri1785	journal	February 2006
Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations Koelsch, Maud; Mallak, Roger; Graham, Garry G. Biochemical Pharmacology, Vol. 79, Issue 8 https://doi.org/10.1016/j.bcp.2009.11.024	journal	April 2010
Mechanism of inhibition of myeloperoxidase by anti-inflammatory drugs Kettle, Anthony J.; Winterbourn, Christine C. Biochemical Pharmacology, Vol. 41, Issue 10 https://doi.org/10.1016/0006-2952(91)90565-m	journal	May 1991
Exploitation of the unusual thermodynamic properties of human myeloperoxidase in inhibitor design Jantschko, Walter; Furtmüller, Paul Georg; Zederbauer, Martina Biochemical Pharmacology, Vol. 69, Issue 8 https://doi.org/10.1016/j.bcp.2005.02.006	journal	April 2005
Puzzling through fragment-based drug design Hajduk, Philip J. Nature Chemical Biology, Vol. 2, Issue 12 https://doi.org/10.1038/nchembio1206-658	journal	December 2006
Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates Forbes, Louisa V.; Sjögren, Tove; Auchère, Françoise Journal of Biological Chemistry, Vol. 288, Issue 51 https://doi.org/10.1074/jbc.m113.507756	journal	December 2013
Myeloperoxidase: friend and foe Klebanoff, Seymour J. Journal of Leukocyte Biology, Vol. 77, Issue 5 https://doi.org/10.1189/jlb.1204697	journal	February 2005
Active site structure and catalytic mechanisms of human peroxidases Furtmüller, Paul G.; Zederbauer, Martina; Jantschko, Walter Archives of Biochemistry and Biophysics, Vol. 445, Issue 2 https://doi.org/10.1016/j.abb.2005.09.017	journal	January 2006
A glass half-full: defining ventilator-associated pneumonia in the neonatal intensive care unit Whitesel, Emily D.; Gupta, Munish Pediatric Research, Vol. 87, Issue 7 https://doi.org/10.1038/s41390-020-0884-8	journal	April 2020
Points of control in inflammation Nathan, Carl Nature, Vol. 420, Issue 6917 https://doi.org/10.1038/nature01320	journal	December 2002
Myeloperoxidase: a target for new drug development?: Inhibition of myeloperoxidase activity Malle, E.; Furtmüller, P. G.; Sattler, W. British Journal of Pharmacology, Vol. 152, Issue 6 https://doi.org/10.1038/sj.bjp.0707358	journal	November 2007
Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes Baldus, Stephan; Heeschen, Christopher; Meinertz, Thomas Circulation, Vol. 108, Issue 12 https://doi.org/10.1161/01.CIR.0000090690.67322.51	journal	September 2003
Neutrophil Extracellular Traps Kill Bacteria Brinkmann, V. Science, Vol. 303, Issue 5663 https://doi.org/10.1126/science.1092385	journal	March 2004
Myeloperoxidase attracts neutrophils by physical forces Klinke, Anna; Nussbaum, Claudia; Kubala, Lukas Blood, Vol. 117, Issue 4 https://doi.org/10.1182/blood-2010-05-284513	journal	January 2011
Application of FASTTM Fragment-Based Lead Discovery and Structure-Guided Design to Discovery of Small Molecule Inhibitors of BCR-ABL Tyrosine Kinase Active Against the T315I Imatinib-Resistant Mutant. Burley, Stephen K. Blood, Vol. 106, Issue 11 https://doi.org/10.1182/blood.V106.11.698.698	journal	November 2005
Aromatic substrate molecules bind at the distal heme pocket of myeloperoxidase. Hori, H.; Fenna, R. E.; Kimura, S. Journal of Biological Chemistry, Vol. 269, Issue 11 https://doi.org/10.1016/S0021-9258(17)37206-X	journal	March 1994
Myeloperoxidase produces nitrating oxidants in vivo Gaut, Joseph P.; Byun, Jaeman; Tran, Hung D. Journal of Clinical Investigation, Vol. 109, Issue 10 https://doi.org/10.1172/JCI0215021	journal	May 2002
Superoxide is an antagonist of anti-inflammatory drugs that inhibit hypochlorous acid production by myeloperoxidase Kettle, Anthony J.; Gedye, Craig A.; Winterbourn, Christine C. Biochemical Pharmacology, Vol. 45, Issue 10 https://doi.org/10.1016/0006-2952(93)90010-T	journal	April 1993
The Effects of Protein Conformation on the Heme Symmetry in High Spin Ferric Heme Proteins as Studied by Electron Paramagnetic Resonance Peisach, J.; Blumberg, W. E.; Ogawa, S. Journal of Biological Chemistry, Vol. 246, Issue 10 https://doi.org/10.1016/S0021-9258(18)62232-X	journal	May 1971
The effect of chloride on the redox and EPR properties of myeloperoxidase. Ikeda-Saito, M.; Prince, R. C. Journal of Biological Chemistry, Vol. 260, Issue 14 https://doi.org/10.1016/S0021-9258(17)39470-X	journal	July 1985
Denaturation and renaturation of myeloperoxidase. Consequences for the nature of the prosthetic group. Wever, R.; Oertling, W. A.; Hoogland, H. Journal of Biological Chemistry, Vol. 266, Issue 36 https://doi.org/10.1016/S0021-9258(18)54229-0	journal	December 1991
Ordered cleavage of myeloperoxidase ester bonds releases active site heme leading to inactivation of myeloperoxidase by benzoic acid hydrazide analogs Huang, Jiansheng; Smith, Forrest; Panizzi, Peter Archives of Biochemistry and Biophysics, Vol. 548 https://doi.org/10.1016/j.abb.2014.02.014	journal	April 2014

Similar Records

ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments

Journal Article · Tue May 19 00:00:00 EDT 2015 · Applied Magnetic Resonance · OSTI ID:1352211

Chavali, Balagopalakrishna; Masquelin, Thierry; Nilges, Mark J.; +6 more

Inhibition of Low Molecular Weight Protein Tyrosine Phosphatase by an Induced-Fit Mechanism

Journal Article · Wed Dec 14 00:00:00 EST 2016 · Journal of Medicinal Chemistry · OSTI ID:1352211

He, Rongjun; Wang, Jifeng; Yu, Zhi-Hong; +4 more

Natively Inhibited Trypanosoma brucei Cathepsin B Structure Determined by Using an X-Ray Laser

Journal Article · Sat Sep 13 00:00:00 EDT 2014 · Science 339:227-230, 2012 · OSTI ID:1352211

Redecke, Lars; Nass, Karol; DePonte, Daniel P.; +18 more

Title: ESR and X-ray Structure Investigations on the Binding and Mechanism of Inhibition of the Native State of Myeloperoxidase with Low Molecular Weight Fragments

Citation Formats

References (32)

Similar Records

Related Subjects