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Title: The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity

Journal Article · · Nature Chemical Biology

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
INDUSTRY
OSTI ID:
1351367
Journal Information:
Nature Chemical Biology, Vol. 13, Issue 3; ISSN 1552-4450
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

References (32)

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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells journal August 2014
Chromatin Modifications and Their Function journal February 2007
Histone H4 deacetylation facilitates 53BP1 DNA damage signaling and double-strand break repair journal January 2013
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination journal September 2007
CRL4Cdt2-Mediated Destruction of the Histone Methyltransferase Set8 Prevents Premature Chromatin Compaction in S Phase journal October 2010
CRL4Cdt2 Regulates Cell Proliferation and Histone Gene Expression by Targeting PR-Set7/Set8 for Degradation journal October 2010
Chromatin proteins and modifications as drug targets journal October 2013
PR-Set7 Is a Nucleosome-Specific Methyltransferase that Modifies Lysine 20 of Histone H4 and Is Associated with Silent Chromatin journal June 2002
The histone H4 Lys 20 methyltransferase PR-Set7 regulates replication origins in mammalian cells journal October 2010
Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer journal October 2013
LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2 journal March 2015
Coot model-building tools for molecular graphics journal November 2004
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin journal June 2004
Regulation of the Histone H4 Monomethylase PR-Set7 by CRL4Cdt2-Mediated PCNA-Dependent Degradation during DNA Damage journal November 2010
Histone H4 Lysine 20 methylation: key player in epigenetic regulation of genomic integrity journal January 2013
Translating the Histone Code journal August 2001
IgH class switching and translocations use a robust non-classical end-joining pathway journal August 2007
Small-Molecule Inhibitors of SETD8 with Cellular Activity journal September 2014
The role of PR-Set7 in replication licensing depends on Suv4-20h journal November 2012
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse journal August 2008
The diverse functions of histone lysine methylation journal November 2005
Certain and Progressive Methylation of Histone H4 at Lysine 20 during the Cell Cycle journal January 2008
Screening for Ligands Using a Generic and High-Throughput Light-Scattering-Based Assay journal December 2006
Structural Chemistry of Human SET Domain Protein Methyltransferases journal August 2011
Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8 journal July 2014
Data processing and analysis with the autoPROC toolbox journal March 2011
Preferential Dimethylation of Histone H4 Lysine 20 by Suv4-20 journal May 2008
Phaser crystallographic software journal July 2007
Automated ligand placement and refinement with a combined force field and shape potential journal June 2006
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription journal February 2012

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