Model of brain activation predicts the neural collective influence map of the brain
[3];
- Levich Institute and Physics Department, City College of New York, New York, NY 10031,
- Levich Institute and Physics Department, City College of New York, New York, NY 10031,, Theoretical Physics, Eidgenössische Technische Hochschule Zürich, 8093 Zürich, Switzerland,
- Center for Polymer Studies and Physics Department, Boston University, Boston, MA 02215
Significance Evidence suggests that the brain is arranged in functionally specialized modules to form a network of networks (NoN). Understanding how functionality emerges from the integration of such modular architectures is one of the greatest scientific challenges. We introduce a model of brain NoN, which is robust against random node failures, captures the integration of functionally specialized modules in the brain, and provides falsifiable predictions about the locations of the most influential nodes, called neural collective influencers, in the brain network—predictions that are impossible in existing but fragile models of interdependent NoN. If confirmed by experiment, our results may pave the way for applications of clinical interest.
- Sponsoring Organization:
- USDOE
- Grant/Contract Number:
- AC07-05Id14517
- OSTI ID:
- 1351030
- Journal Information:
- Proceedings of the National Academy of Sciences of the United States of America, Journal Name: Proceedings of the National Academy of Sciences of the United States of America Vol. 114 Journal Issue: 15; ISSN 0027-8424
- Publisher:
- Proceedings of the National Academy of SciencesCopyright Statement
- Country of Publication:
- United States
- Language:
- English
Web of Science
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