Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury

Alidori, Simone; Akhavein, Nima; Thorek, Daniel L. J.; Behling, Katja; Romin, Yevgeniy; Queen, Dawn; Beattie, Bradley J.; Manova-Todorova, Katia; Bergkvist, Magnus; Scheinberg, David A.; McDevitt, Michael R.

doi:10.1126/scitranslmed.aac9647

Targeted fibrillar nanocarbon RNAi treatment of acute kidney injury

Journal Article · Wed Mar 23 00:00:00 UTC 2016 · Science Translational Medicine

DOI:https://doi.org/10.1126/scitranslmed.aac9647· OSTI ID:1350160

Alidori, Simone ^[1]; Akhavein, Nima ^[1]; Thorek, Daniel L. J. ^[2]; Behling, Katja ^[1]; Romin, Yevgeniy ^[3]; Queen, Dawn ^[1]; Beattie, Bradley J. ^[4]; Manova-Todorova, Katia ^[3]; Bergkvist, Magnus ^[5]; Scheinberg, David A. ^[6]; McDevitt, Michael R. ^[7]

Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Division of Nuclear Medicine and Molecular Imaging, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Molecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
College of Nanoscale Science and Engineering, University at Albany, Albany, NY 12203, USA.
Department of Molecular Pharmacology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA., Department of Pharmacology, Weill Cornell Medical College, New York, NY 10065, USA.
Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA., Department of Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

Fibrillar carbon nanotubes simultaneously deliver two small interfering RNAs, which safely prevent acute kidney injury and prolong survival in mice.

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Sponsoring Organization:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

Grant/Contract Number:: SC0002456

OSTI ID:: 1350160

Journal Information:: Science Translational Medicine, Journal Name: Science Translational Medicine Journal Issue: 331 Vol. 8; ISSN 1946-6234

Publisher:: American Association for the Advancement of Science (AAAS)Copyright Statement

Country of Publication:: United States

Language:: English

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