Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

Burnum-Johnson, Kristin E.; Baker, Erin S.; Metz, Thomas O.

doi:10.1016/j.placenta.2017.03.016

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

Journal Article · Wed Mar 29 00:00:00 EDT 2017 · Placenta (Eastbourne)

DOI:https://doi.org/10.1016/j.placenta.2017.03.016· OSTI ID:1349079

Burnum-Johnson, Kristin E. ^[1]; Baker, Erin S. ^[1]; ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division

A successful pregnancy is dependent upon discrete biological events, which include embryo implantation, decidualization, and placentation. Furthermore, problems associated with each of these events can cause infertility or conditions such as preeclampsia. A greater understanding of the molecular changes associated with these complex processes is necessary to aid in identifying treatments for each condition. Previous nuclear magnetic resonance spectroscopy and mass spectrometry studies have been used to identify metabolites and lipids associated with pregnancy-related complications. However, due to limitations associated with conventional implementations of both techniques, novel technology developments are needed to more fully understand the initiation and development of pregnancy related problems at the molecular level. Here, we describe current analytical techniques for metabolomic and lipidomic characterization of pregnancy complications and discuss the potential for new technologies such as ion mobility spectrometry-mass spectrometry and mass spectrometry imaging to contribute to a better understanding of the molecular changes that affect the placenta and pregnancy outcomes.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1349079

Alternate ID(s):: OSTI ID: 1550476
OSTI ID: 1415694

Report Number(s):: PNNL-SA--123563; PII: S0143400417302175

Journal Information:: Placenta (Eastbourne), Journal Name: Placenta (Eastbourne) Journal Issue: S1 Vol. 60; ISSN 0143-4004

Country of Publication:: United States

Language:: English

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