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Title: Ethylene Regulates Levels of Ethylene Receptor/CTR1 Signaling Complexes in Arabidopsis thaliana

Journal Article · · Journal of Biological Chemistry
 [1];  [2];  [1];  [3];  [1];  [1];  [2]
  1. Dartmouth College, Hanover, NH (United States). Dept. of Biological Sciences; Quaid-i-azam Univ., Islamabad (Pakistan). Dept. of Biochemistry
  2. Dartmouth College, Hanover, NH (United States). Dept. of Biological Sciences
  3. Dartmouth College, Hanover, NH (United States). Dept. of Biological Sciences; Jiangsu Academy of Agricultural Sciences, Nanjing (China). Inst. of Biotechnology
+ Show Author Affiliations

The plant hormone ethylene is perceived by a five-member family of receptors in Arabidopsis thaliana. The receptors function in conjunction with the Raf-like kinase CTR1 to negatively regulate ethylene signal transduction. CTR1 interacts with multiple members of the receptor family based on co-purification analysis, interacting more strongly with receptors containing a receiver domain. Levels of membrane-associated CTR1 vary in response to ethylene, doing so in a post-transcriptional manner that correlates with ethylene-mediated changes in levels of the ethylene receptors ERS1, ERS2, EIN4, and ETR2. Interactions between CTR1 and the receptor ETR1 protect ETR1 from ethylene-induced turnover. Kinetic and dose-response analyses support a model in which two opposing factors control levels of the ethylene receptor/CTR1 complexes. Ethylene stimulates the production of new complexes largely through transcriptional induction of the receptors. However, ethylene also induces turnover of receptors, such that levels of ethylene receptor/CTR1 complexes decrease at higher ethylene concentrations. Lastly, we discuss implications of this model for ethylene signaling.

Research Organization:
Dartmouth College, Hanover, NH (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES); Higher Education Commission of Pakistan
Contributing Organization:
Quaid-i-azam Univ., Islamabad (Pakistan); Jiangsu Academy of Agricultural Sciences, Nanjing (China)
Grant/Contract Number:
FG02-05ER15704
OSTI ID:
1348379
Journal Information:
Journal of Biological Chemistry, Vol. 290, Issue 19; ISSN 0021-9258
Publisher:
American Society for Biochemistry and Molecular BiologyCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 53 works
Citation information provided by
Web of Science

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Cited By (13)

Amplification and Adaptation in the Ethylene Signaling Pathway journal October 2019
Differentially localized rice ethylene receptors OsERS1 and OsETR2 and their potential role during submergence journal August 2017
RNA-seq assistant: machine learning based methods to identify more transcriptional regulated genes journal July 2018
Identification of a stable major-effect QTL (Parth 2.1) controlling parthenocarpy in cucumber and associated candidate gene analysis via whole genome re-sequencing journal August 2016
The Role of Ethylene in Plants Under Salinity Stress journal November 2015
Ethylene and Metal Stress: Small Molecule, Big Impact journal February 2016
New Insights in Transcriptional Regulation of the Ethylene Response in Arabidopsis journal June 2019
A Functional Connection between the Circadian Clock and Hormonal Timing in Arabidopsis journal November 2018
Plant Hormone Signaling Crosstalks between Biotic and Abiotic Stress Responses journal October 2018
Differentially localized rice ethylene receptors OsERS1 and OsETR2 and their potential role during submergence text January 2017
The Pivotal Role of Ethylene in Plant Growth journal April 2018
A Complex Molecular Interplay of Auxin and Ethylene Signaling Pathways Is Involved in Arabidopsis Growth Promotion by Burkholderia phytofirmans PsJN journal April 2016
Ethylene-Related Gene Expression Networks in Wood Formation journal March 2018

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59 BASIC BIOLOGICAL SCIENCES
Arabidopsis
ethylene
histidine kinase
hormone receptor
membrane protein
protein complex
protein turnover
serine/threonine protein kinase