Identification of Coq11, a New Coenzyme Q Biosynthetic Protein in the CoQ-Synthome in Saccharomyces cerevisiae

Allan, Christopher M.; Awad, Agape M.; Johnson, Jarrett S.; Shirasaki, Dyna I.; Wang, Charles; Blaby-Haas, Crysten E.; Merchant, Sabeeha S.; Loo, Joseph A.; Clarke, Catherine F.

doi:10.1074/jbc.m114.633131

Identification of Coq11, a New Coenzyme Q Biosynthetic Protein in the CoQ-Synthome in Saccharomyces cerevisiae

Journal Article · Wed Jan 28 00:00:00 EST 2015 · Journal of Biological Chemistry

DOI:https://doi.org/10.1074/jbc.m114.633131· OSTI ID:1348353

Allan, Christopher M. ^[1]; Awad, Agape M. ^[2]; Johnson, Jarrett S. ^[2]; Shirasaki, Dyna I. ^[2]; Wang, Charles ^[2]; Blaby-Haas, Crysten E. ^[2]; Merchant, Sabeeha S. ^[3]; Loo, Joseph A. ^[4]; Clarke, Catherine F. ^[2]

Univ. of California, Los Angeles, CA (United States). Dept. of Chemistry and Biochemistry. Molecular Biology Inst.; DOE Office of Scientific and Technical Information (OSTI)
Univ. of California, Los Angeles, CA (United States). Dept. of Chemistry and Biochemistry. Molecular Biology Inst.
Univ. of California, Los Angeles, CA (United States). Dept. of Chemistry and Biochemistry. Molecular Biology Inst. UCLA/DOE Inst. for Genomics and Proteomics
Univ. of California, Los Angeles, CA (United States). Dept. of Chemistry and Biochemistry. Molecular Biology Inst. UCLA/DOE Inst. for Genomics and Proteomics. Dept. of Biological Chemistry

Coenzyme Q (Q or ubiquinone) is a redox active lipid composed of a fully substituted benzoquinone ring and a polyisoprenoid tail and is required for mitochondrial electron transport. In the yeast Saccharomyces cerevisiae, Q is synthesized by the products of 11 known genes, COQ1–COQ9, YAH1, and ARH1. The function of some of the Coq proteins remains unknown, and several steps in the Q biosynthetic pathway are not fully characterized. Several of the Coq proteins are associated in a macromolecular complex on the matrix face of the inner mitochondrial membrane, and this complex is required for efficient Q synthesis. In this paper, we further characterize this complex via immunoblotting and proteomic analysis of tandem affinity-purified tagged Coq proteins. We show that Coq8, a putative kinase required for the stability of the Q biosynthetic complex, is associated with a Coq6-containing complex. Additionally Q₆ and late stage Q biosynthetic intermediates were also found to co-purify with the complex. A mitochondrial protein of unknown function, encoded by the YLR290C open reading frame, is also identified as a constituent of the complex and is shown to be required for efficient de novo Q biosynthesis. Finally, given its effect on Q synthesis and its association with the biosynthetic complex, we propose that the open reading frame YLR290C be designated COQ11.

View Accepted Manuscript (DOE)

Research Organization:: Univ. of California, Los Angeles, CA (United States)

Sponsoring Organization:: National Inst. of Health (NIH) (United States); National Science Foundation (NSF) (United States); USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)

Grant/Contract Number:: FC02-02ER63421

OSTI ID:: 1348353

Journal Information:: Journal of Biological Chemistry, Journal Name: Journal of Biological Chemistry Journal Issue: 12 Vol. 290; ISSN 0021-9258

Publisher:: American Society for Biochemistry and Molecular BiologyCopyright Statement

Country of Publication:: United States

Language:: English

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CoQ10 production in Schizosaccharomyces pombe is increased by reduction of glucose levels or deletion of pka1 Nishida, Ikuhisa; Yokomi, Kazumasa; Hosono, Kouji Applied Microbiology and Biotechnology, Vol. 103, Issue 12 https://doi.org/10.1007/s00253-019-09843-7	journal	April 2019
Reduction in the levels of CoQ biosynthetic proteins is related to an increase in lifespan without evidence of hepatic mitohormesis Rodríguez-Hidalgo, María; Luna-Sánchez, Marta; Hidalgo-Gutiérrez, Agustín Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-32190-y	journal	September 2018
Biosynthesis of coenzyme Q in eukaryotes Kawamukai, Makoto Bioscience, Biotechnology, and Biochemistry, Vol. 80, Issue 1 https://doi.org/10.1080/09168451.2015.1065172	journal	July 2015
Schizosaccharomyces japonicus has low levels of CoQ ₁₀ synthesis, respiration deficiency, and efficient ethanol production Kaino, Tomohiro; Tonoko, Kai; Mochizuki, Shiomi Bioscience, Biotechnology, and Biochemistry, Vol. 82, Issue 6 https://doi.org/10.1080/09168451.2017.1401914	journal	December 2017
Biosynthesis and applications of prenylquinones Kawamukai, Makoto Bioscience, Biotechnology, and Biochemistry, Vol. 82, Issue 6 https://doi.org/10.1080/09168451.2018.1433020	journal	February 2018
Coenzyme Q10 Supplementation in Aging and Disease Hernández-Camacho, Juan D.; Bernier, Michel; López-Lluch, Guillermo Frontiers in Physiology, Vol. 9 https://doi.org/10.3389/fphys.2018.00044	journal	February 2018
Schizosaccharomyces japonicus has low levels of CoQ₁₀ synthesis, respiration deficiency, and efficient ethanol production Kaino, Tomohiro; Tonoko, Kai; Mochizuki, Shiomi Taylor & Francis https://doi.org/10.6084/m9.figshare.5657302.v1	text	January 2017

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