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Title: Human CaaX protease ZMPSTE24 expressed in yeast: Structure and inhibition by HIV protease inhibitors: ZMPSTE24 Structure and Inhibition

Journal Article · · Protein Science
DOI:https://doi.org/10.1002/pro.3074· OSTI ID:1347782
 [1];  [2];  [1];  [3]
  1. Department of Pediatrics, University of Rochester Medical Center, Rochester New York 14642
  2. Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester New York 14642
  3. Department of Pediatrics, University of Rochester Medical Center, Rochester New York 14642; Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester New York 14642

Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
National Institutes of Health (NIH)
OSTI ID:
1347782
Journal Information:
Protein Science, Vol. 26, Issue 2; ISSN 0961-8368
Publisher:
The Protein Society
Country of Publication:
United States
Language:
ENGLISH

References (19)

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HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells journal July 2007
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The Protease Ste24 Clears Clogged Translocons journal January 2016
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HIV-protease inhibitors block the enzymatic activity of purified Ste24p journal September 2008
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Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity journal June 2012
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Structure of the Integral Membrane Protein CAAX Protease Ste24p journal March 2013
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Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome journal April 2003
The Structural Basis of ZMPSTE24-Dependent Laminopathies journal March 2013
The PDB_REDO server for macromolecular structure model optimization journal May 2014