Linkage disequilibrium at the human dopamine D2 receptor locus (DRD2) in three populations from Taiwan

Journal Article · Thu Sep 01 04:00:00 EDT 1994 · American Journal of Human Genetics

OSTI ID:134659

Ko, H C ^[1]; Lu, R B ^[2]; Chang, F M ^[3]

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1. National Cheng Kung Univ., Tainan (Taiwan, Province of China)
2. National Defense Medical Center, Taipei (Taiwan, Province of China)
3. Yale Univ., New Haven, CT (United States); and others

There are now at least several polymorphisms distributed across the coding regions of DRD2. The TaqI A and B systems are roughly 30 kb apart; the TaqI A system is about 10 kb downstream from the last exon and the TaqI B system is about 5 kb upstream of exon 2 (which contains the initiation codon). Previous studies in U.S. Blacks and Caucasians have show significant linkage disequilibrium. We have studied three ethnic groups living on Taiwan: Chinese Han (44 individuals), Atayal (41 individuals) and Ami (40 individuals). All three groups show significant linkage disequilibrium between the TaqI A and TaqI B systems. The haplotype frequencies differ significantly among the three groups, Blacks and Caucasians; the magnitude of disequilibrium also differs among the six. However, all six groups show a pattern of higher than expected frequencies of A1B1 and A2B2, and lower than expected frequencies of A1B2 and A2B1.

• OSTI ID: 134659
• Report Number(s): CONF-941009--
• Journal Information: American Journal of Human Genetics, Journal Name: American Journal of Human Genetics Journal Issue: Suppl.3 Vol. 55; ISSN AJHGAG; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
CODONS
DETECTION
DOPAMINE
EXONS
GENE MUTATIONS
GENES
HUMAN POPULATIONS
RECEPTORS
STATISTICS
TAIWAN