Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging

Ho, I-Ting; Sessler, Jonathan L.; Gambhir, Sanjiv Sam; Jokerst, Jesse V.

doi:10.1039/c5an00207a

Title: Parts per billion detection of uranium with a porphyrinoid-containing nanoparticle and in vivo photoacoustic imaging

Journal Article · Wed Apr 01 00:00:00 EDT 2015 · Analyst

DOI:https://doi.org/10.1039/c5an00207a· OSTI ID:1346160

Ho, I-Ting ^[1]; Sessler, Jonathan L. ^[1]; Gambhir, Sanjiv Sam ^[2]; Jokerst, Jesse V. ^[3]

Univ. of Texas, Austin, TX (United States). Dept. of Chemistry
Stanford Univ., Stanford, CA (United States)
Stanford Univ., Stanford, CA (United States) (United States). School of Medicine, Dept. of Radiology

Chemical tools that can report radioactive isotopes would be of interest to the defense community. Here in this paper we report –250 nm polymeric nanoparticles containing porphyrinoid macrocycles with and without pre-complexed depleted uranium and demonstrate that the latter species may be detected easily and with high sensitivity via photoacoustic imaging. The porphyrinoid macrocycles used in the present study are non-aromatic in the absence of the uranyl cation, but aromatic after cation complexation. We solubilized both the freebase and metalated forms of the macrocycles in poly(lactic-co-glycolic acid) and found a peak in the photoacoustic spectrum at 910 nm excitation in the case of the uranyl complex. The signal was stable for at least 15 minutes and allowed detection of uranium concentrations down to 6.2 ppb (5.7 nM) in vitro and 0.57 ppm (19 fCi; 0.52 μM) in vivo. Furthermore, to the best of our knowledge, this is the first report of a nanoparticle that detects an actinide cation via photoacoustic imaging.

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Research Organization:: Univ. of Texas, Austin, TX (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FG02-01ER15186

OSTI ID:: 1346160

Journal Information:: Analyst, Vol. 140, Issue 11; ISSN 0003-2654

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 52 works

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References (42)

Lutetium Texaphyrin (PCI-0123): A Near-Infrared, Water-Soluble Photosensitizer Young, S. W.; Woodburn, K. W.; Wright, M. Photochemistry and Photobiology, Vol. 63, Issue 6 https://doi.org/10.1111/j.1751-1097.1996.tb09647.x	journal	June 1996
Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs Wang, L. V.; Hu, S. Science, Vol. 335, Issue 6075 https://doi.org/10.1126/science.1216210	journal	March 2012
Gadolinium(III) texaphyrin: a tumor selective radiation sensitizer that is detectable by MRI. Young, S. W.; Qing, F.; Harriman, A. Proceedings of the National Academy of Sciences, Vol. 93, Issue 13 https://doi.org/10.1073/pnas.93.13.6610	journal	June 1996
Fluorescence and absorbance spectroscopy of the uranyl ion in nitric acid for process monitoring applications Smith, Nicholas A.; Cerefice, Gary S.; Czerwinski, Kenneth R. Journal of Radioanalytical and Nuclear Chemistry, Vol. 295, Issue 2 https://doi.org/10.1007/s10967-012-1942-4	journal	July 2012
Laser-Induced Shape Changes of Colloidal Gold Nanorods Using Femtosecond and Nanosecond Laser Pulses Link, S.; Burda, C.; Nikoobakht, B. The Journal of Physical Chemistry B, Vol. 104, Issue 26 https://doi.org/10.1021/jp000679t	journal	July 2000
Carbon nanotubes as photoacoustic molecular imaging agents in living mice De La Zerda, Adam; Zavaleta, Cristina; Keren, Shay Nature Nanotechnology, Vol. 3, Issue 9 https://doi.org/10.1038/nnano.2008.231	journal	August 2008
A Hybrid Macrocycle with a Pyridine Subunit Displays Aromatic Character upon Uranyl Cation Complexation Ho, I-Ting; Zhang, Zhan; Ishida, Masatoshi Journal of the American Chemical Society, Vol. 136, Issue 11 https://doi.org/10.1021/ja412520g	journal	March 2014
meso -Tetrakis( p -sulfonatophenyl)N-Confused Porphyrin Tetrasodium Salt: A Potential Sensitizer for Photodynamic Therapy Thomas, Ajesh P.; Saneesh Babu, P. S.; Asha Nair, S. Journal of Medicinal Chemistry, Vol. 55, Issue 11 https://doi.org/10.1021/jm300009q	journal	June 2012
Synthesis of Polymer–Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy Mieszawska, Aneta J.; Kim, YongTae; Gianella, Anita Bioconjugate Chemistry, Vol. 24, Issue 9 https://doi.org/10.1021/bc400166j	journal	August 2013
Gold Nanorods for Ovarian Cancer Detection with Photoacoustic Imaging and Resection Guidance via Raman Imaging in Living Mice Jokerst, Jesse V.; Cole, Adam J.; Van de Sompel, Dominique ACS Nano, Vol. 6, Issue 11 https://doi.org/10.1021/nn304347g	journal	October 2012
Determination of uranium in tap water by ICP-MS Himri, M. El; Pastor, A.; de la Guardia, M. Fresenius' Journal of Analytical Chemistry, Vol. 367, Issue 2 https://doi.org/10.1007/s002160051616	journal	May 2000
Porphysome nanovesicles generated by porphyrin bilayers for use as multimodal biophotonic contrast agents Lovell, Jonathan F.; Jin, Cheng S.; Huynh, Elizabeth Nature Materials, Vol. 10, Issue 4 https://doi.org/10.1038/nmat2986	journal	March 2011
Photoacoustic ultrasound Kruger, Robert A. Medical Physics, Vol. 21, Issue 1 https://doi.org/10.1118/1.597367	journal	January 1994
Observation of radiation-specific damage in cells exposed to depleted uranium: hprt gene mutation frequency Miller, Alexandra C.; Stewart, Michael; Rivas, Rafael Radiation Measurements, Vol. 42, Issue 6-7 https://doi.org/10.1016/j.radmeas.2007.05.022	journal	July 2007
Multispectral opto-acoustic tomography of deep-seated fluorescent proteins in vivo Razansky, Daniel; Distel, Martin; Vinegoni, Claudio Nature Photonics, Vol. 3, Issue 7 https://doi.org/10.1038/nphoton.2009.98	journal	June 2009
Oxidation-state-specific detection of uranium in aqueous solution by photoacoustic spectroscopy Schrepp, W.; Stumpe, R.; Kim, J. I. Applied Physics B Photophysics and Laser Chemistry, Vol. 32, Issue 4 https://doi.org/10.1007/BF00688289	journal	December 1983
Emergency response by robots to Fukushima‐Daiichi accident: summary and lessons learned Kawatsuma, Shinji; Fukushima, Mineo; Okada, Takashi Industrial Robot: An International Journal, Vol. 39, Issue 5 https://doi.org/10.1108/01439911211249715	journal	August 2012
Semiconducting polymer nanoparticles as photoacoustic molecular imaging probes in living mice Pu, Kanyi; Shuhendler, Adam J.; Jokerst, Jesse V. Nature Nanotechnology, Vol. 9, Issue 3 https://doi.org/10.1038/nnano.2013.302	journal	January 2014
A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle Kircher, Moritz F.; de la Zerda, Adam; Jokerst, Jesse V. Nature Medicine, Vol. 18, Issue 5 https://doi.org/10.1038/nm.2721	journal	April 2012
Prodigiosin Analogue Designed for Metal Coordination: Stable Zinc and Copper Pyrrolyldipyrrins Chang, Tsuhen M.; Sinharay, Sanhita; Astashkin, Andrei V. Inorganic Chemistry, Vol. 53, Issue 14 https://doi.org/10.1021/ic5008439	journal	June 2014
Preparation and Growth Mechanism of Gold Nanorods (NRs) Using Seed-Mediated Growth Method Nikoobakht, Babak; El-Sayed, Mostafa A. Chemistry of Materials, Vol. 15, Issue 10 https://doi.org/10.1021/cm020732l	journal	May 2003
The role of porphyrin chemistry in tumor imaging and photodynamic therapy Ethirajan, Manivannan; Chen, Yihui; Joshi, Penny Chem. Soc. Rev., Vol. 40, Issue 1 https://doi.org/10.1039/B915149B	journal	January 2011
Construction and Validation of Nano Gold Tripods for Molecular Imaging of Living Subjects Cheng, Kai; Kothapalli, Sri-Rajasekhar; Liu, Hongguang Journal of the American Chemical Society, Vol. 136, Issue 9 https://doi.org/10.1021/ja412001e	journal	February 2014
On the Hydrolysis of the Tetravalent Uranium Ion U4+ Manfredi, Carla; Caruso, Vincenzo; Vasca, Ermanno Journal of Solution Chemistry, Vol. 35, Issue 7 https://doi.org/10.1007/s10953-006-9037-x	journal	June 2006
Photoacoustic Evaluation of Volume and Entropy Changes in Energy and Electron Transfer. Triplet State Porphyrin with Oxygen and Naphthoquinone-2-Sulfonate Feitelson, Jehuda; Mauzerall, David The Journal of Physical Chemistry, Vol. 100, Issue 18 https://doi.org/10.1021/jp953322b	journal	January 1996
Mechanisms of Uranium Interactions with Hydroxyapatite: Implications for Groundwater Remediation Fuller, C. C.; Bargar, J. R.; Davis, J. A. Environmental Science & Technology, Vol. 36, Issue 2 https://doi.org/10.1021/es0108483	journal	January 2002
Development of highly porous large PLGA microparticles for pulmonary drug delivery Yang, Yan; Bajaj, Nimisha; Xu, Peisheng Biomaterials, Vol. 30, Issue 10 https://doi.org/10.1016/j.biomaterials.2008.12.044	journal	April 2009
Water-soluble porphyrin nanospheres: enhanced photo-physical properties achieved via cyclodextrin driven double self-inclusion Zhang, Hong; Zhang, Boyu; Zhu, Mengyuan Chem. Commun., Vol. 50, Issue 37 https://doi.org/10.1039/C4CC01372G	journal	January 2014
Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging Agarwal, A.; Huang, S. W.; O’Donnell, M. Journal of Applied Physics, Vol. 102, Issue 6 https://doi.org/10.1063/1.2777127	journal	September 2007
Speciation of Uranium in Aqueous Solutions and in Precipitates by Photoacoustic Spectroscopy Kimura, T.; Serrano G., J.; Nakayama, S. ract, Vol. 58-59, Issue 1 https://doi.org/10.1524/ract.1992.5859.1.173	journal	May 1992
Quantitation of Metal Content in the Silver-Assisted Growth of Gold Nanorods Orendorff, Christopher J.; Murphy, Catherine J. The Journal of Physical Chemistry B, Vol. 110, Issue 9 https://doi.org/10.1021/jp0570972	journal	March 2006
Photoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods Jokerst, Jesse V.; Thangaraj, Mridhula; Kempen, Paul J. ACS Nano, Vol. 6, Issue 7 https://doi.org/10.1021/nn302042y	journal	June 2012
In vivo magnetic enrichment and multiplex photoacoustic detection of circulating tumour cells Galanzha, Ekaterina I.; Shashkov, Evgeny V.; Kelly, Thomas Nature Nanotechnology, Vol. 4, Issue 12 https://doi.org/10.1038/nnano.2009.333	journal	November 2009
PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution Mainardes, Rubiana M.; Evangelista, Raul C. International Journal of Pharmaceutics, Vol. 290, Issue 1-2 https://doi.org/10.1016/j.ijpharm.2004.11.027	journal	February 2005
Fabrication of covered porous PLGA microspheres using hydrogen peroxide for controlled drug delivery and regenerative medicine Bae, Soon Eon; Son, Jun Sik; Park, Kwideok Journal of Controlled Release, Vol. 133, Issue 1 https://doi.org/10.1016/j.jconrel.2008.09.006	journal	January 2009
Silica-Coated Gold Nanorods as Photoacoustic Signal Nanoamplifiers Chen, Yun-Sheng; Frey, Wolfgang; Kim, Seungsoo Nano Letters, Vol. 11, Issue 2 https://doi.org/10.1021/nl1042006	journal	February 2011
Condensed phase photoacoustic spectroscopic detection of porphyrins and dyes Voigtman, Edward.; Jurgensen, Arthur.; Winefordner, James. Analytical Chemistry, Vol. 53, Issue 9 https://doi.org/10.1021/ac00232a031	journal	August 1981
Molecular Imaging by Means of Multispectral Optoacoustic Tomography (MSOT) Ntziachristos, Vasilis; Razansky, Daniel Chemical Reviews, Vol. 110, Issue 5 https://doi.org/10.1021/cr9002566	journal	May 2010
Effect of porosity on the release kinetics of propafenone-loaded PEG-g-PLA nanoparticles Sant, Shilpa; Nadeau, Véronique; Hildgen, Patrice Journal of Controlled Release, Vol. 107, Issue 2 https://doi.org/10.1016/j.jconrel.2005.02.017	journal	October 2005
Non-invasive multimodal functional imaging of the intestine with frozen micellar naphthalocyanines Zhang, Yumiao; Jeon, Mansik; Rich, Laurie J. Nature Nanotechnology, Vol. 9, Issue 8 https://doi.org/10.1038/nnano.2014.130	journal	July 2014
A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications James, Michelle L.; Gambhir, Sanjiv S. Physiological Reviews, Vol. 92, Issue 2 https://doi.org/10.1152/physrev.00049.2010	journal	April 2012
Dedicated 3D photoacoustic breast imaging: Dedicated 3D photoacoustic breast imaging Kruger, Robert A.; Kuzmiak, Cherie M.; Lam, Richard B. Medical Physics, Vol. 40, Issue 11 https://doi.org/10.1118/1.4824317	journal	October 2013

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Porphyrins in troubled times: a spotlight on porphyrins and their metal complexes for explosives testing and CBRN defense Kielmann, Marc; Prior, Caroline; Senge, Mathias O. New Journal of Chemistry, Vol. 42, Issue 10 https://doi.org/10.1039/c7nj04679k	journal	January 2018
Structure and magnetism of a tetrahedral uranium( iii ) β-diketiminate complex Boreen, Michael A.; Gould, Colin A.; Booth, Corwin H. Dalton Transactions, Vol. 49, Issue 23 https://doi.org/10.1039/d0dt01599g	journal	January 2020
Strategies for Image-Guided Therapy, Surgery, and Drug Delivery Using Photoacoustic Imaging Moore, Colman; Jokerst, Jesse V. Theranostics, Vol. 9, Issue 6 https://doi.org/10.7150/thno.32362	journal	January 2019
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An example of unusual pyridine donor Schiff base uranyl (UO ₂ ²⁺ ) complexes Hardy, E. E.; Wyss, K. M.; Eddy, M. A. Chemical Communications, Vol. 53, Issue 42 https://doi.org/10.1039/c7cc02747h	journal	January 2017
Photoacoustic Probes for Molecular Detection: Recent Advances and Perspectives Zeng, Leli; Ma, Gongcheng; Lin, Jing Small, Vol. 14, Issue 30 https://doi.org/10.1002/smll.201800782	journal	June 2018
New supporting ligands in actinide chemistry: tetramethyltetraazaannulene complexes with thorium and uranium Hohloch, Stephan; Garner, Mary E.; Parker, Bernard F. Dalton Trans., Vol. 46, Issue 40 https://doi.org/10.1039/c7dt02682j	journal	January 2017
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