Bulk production and evaluation of high specific activity 186g Re for cancer therapy using enriched 186 WO 3 targets in a proton beam

Mastren, Tara; Radchenko, Valery; Bach, Hong T.; Balkin, Ethan R.; Birnbaum, Eva R.; Brugh, Mark; Engle, Jonathan W.; Gott, Matthew D.; Guthrie, James; Hennkens, Heather M.; John, Kevin D.; Ketring, Alan R.; Kuchuk, Marina; Maassen, Joel R.; Naranjo, Cleo M.; Nortier, F. Meiring; Phelps, Tim E.; Jurisson, Silvia S.; Wilbur, D. Scott; Fassbender, Michael E.

doi:10.1016/j.nucmedbio.2017.02.006

Title: Bulk production and evaluation of high specific activity 186g Re for cancer therapy using enriched 186 WO 3 targets in a proton beam

Journal Article · Thu Jun 01 00:00:00 EDT 2017 · Nuclear Medicine and Biology

DOI:https://doi.org/10.1016/j.nucmedbio.2017.02.006· OSTI ID:1345946

Mastren, Tara; Radchenko, Valery; Bach, Hong T.; Balkin, Ethan R.; Birnbaum, Eva R.; Brugh, Mark; Engle, Jonathan W.; Gott, Matthew D.; Guthrie, James; Hennkens, Heather M.; John, Kevin D.; Ketring, Alan R.; Kuchuk, Marina; Maassen, Joel R.; Naranjo, Cleo M.; Nortier, F. Meiring; Phelps, Tim E.; Jurisson, Silvia S.; Wilbur, D. Scott; Fassbender, Michael E.

Rhenium-186 g (t_1/2 = 3.72 d) is a β– emitting isotope suitable for theranostic applications. Current production methods rely on reactor production by way of the reaction ¹⁸⁵Re(n,γ)^186gRe, which results in low specific activities limiting its use for cancer therapy. Production via charged particle activation of enriched ¹⁸⁶W results in a ^186gRe product with a much specific activity, allowing it to be used more broadly for targeted radiotherapy applications. Furthermore, this targets the unmet clinical need for more efficient radiotherapeutics.

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Research Organization:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Nuclear Physics (NP)

Grant/Contract Number:: AC52-06NA25396

OSTI ID:: 1345946

Alternate ID(s):: OSTI ID: 1415249

Report Number(s):: LA-UR-16-29352; TRN: US1700520

Journal Information:: Nuclear Medicine and Biology, Vol. 49, Issue C; ISSN 0969-8051

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 16 works

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Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment Feng, Yutian; Phelps, Tim E.; Carroll, Valerie Dalton Transactions, Vol. 46, Issue 42 https://doi.org/10.1039/c7dt02407j	journal	January 2017

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