Inv(7)(q22q36) in refactory anemia with excess blasts
- Oncogenetics, Phoenix, AZ (United States); and others
Morphological review of bone marrow from an 89 year-old male revealed an immature cell population with increased blasts (25% CD34 positive). However, the morphology was not sufficiently clear to discriminate lymphoid from myeloid precursors. Immunophenotypically, there was evidence for both lymphoid and myeloid derivation with dual expression of CD5 and CD20, aberrant expression of CD19 versus CD20, and an increased CD13 population. Twenty percent (20%) of the cells were TdT positive. Cytogenetically, an inversion of chromosome 7, inv(7)(q22q36), was observed in 9 of 20 cells. This abnormality has been reported only once previously, in association with refractory anemia with excess blasts (RAEB). The patient, to date, has not developed an acute leukemic process, but remains in a myelodysplastic state, defined as RAEB.
- OSTI ID:
- 134542
- Report Number(s):
- CONF-941009-; ISSN 0002-9297; TRN: 95:005313-1276
- Journal Information:
- American Journal of Human Genetics, Vol. 55, Issue Suppl.3; Conference: 44. annual meeting of the American Society of Human Genetics, Montreal (Canada), 18-22 Oct 1994; Other Information: PBD: Sep 1994
- Country of Publication:
- United States
- Language:
- English
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