Regulation and disregulation of mammalian nucleotide excision repair: A pathway to nongermline breast carcinogenesis

Latimer, Jean J.; Majekwana, Vongai J.; Pabon-Padin, Yashira R.; Pimpley, Manasi R.; Grant, Stephen G.

doi:10.1111/php.12387

Regulation and disregulation of mammalian nucleotide excision repair: A pathway to nongermline breast carcinogenesis

Journal Article · Fri Dec 19 00:00:00 EST 2014 · Photochemistry and Photobiology

DOI:https://doi.org/10.1111/php.12387· OSTI ID:1344921

Latimer, Jean J. ^[1]; Majekwana, Vongai J. ^[2]; Pabon-Padin, Yashira R. ^[2]; Pimpley, Manasi R. ^[2]; Grant, Stephen G. ^[2]

Nova Southeastern Univ., Fort Lauderdale, FL (United States); DOE Office of Scientific and Technical Information (OSTI)
Nova Southeastern Univ., Fort Lauderdale, FL (United States)

Nucleotide excision repair (NER) is important as a modulator of disease, especially in constitutive deficiencies, such as the cancer predisposition syndrome Xeroderma pigmentosum. We have found profound variation of NER capacity among normal individuals, between cell-types and during carcinogenesis. NER is a repair system for many types of DNA damage, and therefore many types of genotoxic carcinogenic exposures, including ultraviolet light, products of organic combustion, metals, oxidative stress, etc. Since NER is intimately related to cellular metabolism, requiring components of both the DNA replicative and transcription machinery, it has a narrow range of functional viability. Thus, genes in the NER pathway are expressed at the low levels manifested by, for example, nuclear transcription factors. Since NER activity and gene expression vary by cell-type, it is inherently epigenetically regulated. Furthermore, this epigenetic regulation is disregulated during sporadic breast carcinogenesis. Loss of NER is one basis of genomic instability, a required element in cellular transformation, and one that potentially modulates response to therapy. In this article, we demonstrate differences in NER capacity in eight adult mouse tissues, and place this result into the context of our previous work on mouse extraembryonic tissues, normal human tissues and sporadic early stage human breast cancer.

View Accepted Manuscript (DOE)

Research Organization:: Nova Southeastern Univ., Fort Lauderdale, FL (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC03-76SF01012

OSTI ID:: 1344921

Journal Information:: Photochemistry and Photobiology, Journal Name: Photochemistry and Photobiology Journal Issue: 2 Vol. 91; ISSN 0031-8655

Publisher:: The American Society of PhotobiologyCopyright Statement

Country of Publication:: United States

Language:: English

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