APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress

Wallace, Bret D.; Berman, Zachary; Mueller, Geoffrey A.; Lin, Yunfeng; Chang, Timothy; Andres, Sara N.; Wojtaszek, Jessica L.; DeRose, Eugene F.; Appel, C. Denise; London, Robert E.; Yan, Shan; Williams, R. Scott

doi:10.1073/pnas.1610011114

Title: APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress

Journal Article · Tue Dec 27 00:00:00 EST 2016 · Proceedings of the National Academy of Sciences of the United States of America

DOI:https://doi.org/10.1073/pnas.1610011114· OSTI ID:1343137

Wallace, Bret D. ^[1]; Berman, Zachary ^[2]; Mueller, Geoffrey A. ^[1]; Lin, Yunfeng ^[2]; Chang, Timothy ^[1]; Andres, Sara N. ^[1]; Wojtaszek, Jessica L. ^[1]; DeRose, Eugene F. ^[1]; Appel, C. Denise ^[1]; London, Robert E. ^[1]; Yan, Shan ^[2]; Williams, R. Scott ^[1]

National Inst. of Health, Triangle Park, NC (United States)
Univ. of North Carolina, Charlotte, NC (United States)

The Xenopus laevis APE2 (apurinic/apyrimidinic endonuclease 2) nuclease participates in 3'-5' nucleolytic resection of oxidative DNA damage and activation of the ATR-Chk1 DNA damage response (DDR) pathway via ill-defined mechanisms. Here we report that APE2 resection activity is regulated by DNA interactions in its Zf-GRF domain, a region sharing high homology with DDR proteins Topoisomerase 3α (TOP3α) and NEIL3 (Nei-like DNA glycosylase 3), as well as transcription and RNA regulatory proteins, such as TTF2 (transcription termination factor 2), TFIIS, and RPB9. Biochemical and NMR results establish the nucleic acid-binding activity of the Zf-GRF domain. Moreover, an APE2 Zf-GRF X-ray structure and small-angle X-ray scattering analyses show that the Zf-GRF fold is typified by a crescent-shaped ssDNA binding claw that is flexibly appended to an APE2 endonuclease/exonuclease/phosphatase (EEP) catalytic core. Structure-guided Zf-GRF mutations impact APE2 DNA binding and 3'-5' exonuclease processing, and also prevent efficient APE2-dependent RPA recruitment to damaged chromatin and activation of the ATR-Chk1 DDR pathway in response to oxidative stress in Xenopus egg extracts. Collectively, our data unveil the APE2 Zf-GRF domain as a nucleic acid interaction module in the regulation of a key single-strand break resection function of APE2, and also reveal topologic similarity of the Zf-GRF to the zinc ribbon domains of TFIIS and RPB9.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); USDOE Office of Science (SC), Biological and Environmental Research (BER); Univ. of North Carolina at Charlotte; National Inst. of General Medical Sciences of the National Inst. of Health (NIH)

Grant/Contract Number:: W-31-109-Eng-38; R15 GM101571; R15 GM114713; R01 GM105404; 1Z01ES102765; 1Z01ES050111

OSTI ID:: 1343137

Journal Information:: Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, Issue 2; ISSN 0027-8424

Publisher:: National Academy of SciencesCopyright Statement

Country of Publication:: United States

Language:: ENGLISH

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Cited by: 37 works

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59 BASIC BIOLOGICAL SCIENCES
oxidative stress
APE2
Zf-GRF
crystallography
Xenopus laevis

Title: APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress

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