Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids

Lau, King Hang Aaron; Sileika, Tadas S.; Park, Sung Hyun; Sousa, Ana M. L.; Burch, Patrick; Szleifer, Igal; Messersmith, Phillip B.

doi:10.1002/admi.201400225

Molecular Design of Antifouling Polymer Brushes Using Sequence-Specific Peptoids

Journal Article · Tue Nov 25 23:00:00 EST 2014 · Advanced Materials Interfaces

DOI:https://doi.org/10.1002/admi.201400225· OSTI ID:1343092

Lau, King Hang Aaron ^[1]; Sileika, Tadas S. ^[2]; Park, Sung Hyun ^[2]; Sousa, Ana M. L. ^[3]; Burch, Patrick ^[2]; Szleifer, Igal ^[4]; Messersmith, Phillip B. ^[2]

Northwestern Univ., Evanston, IL (United States). Biomedical Engineering Dept., Chemistry of Life Processes Inst.; Office of Scientific and Technical Information (OSTI)
Northwestern Univ., Evanston, IL (United States). Biomedical Engineering Dept., Chemistry of Life Processes Inst.
Univ. of Strathclyde, Glasgow (United Kingdom). Depy. of Pure and Applied Chemistry
Northwestern Univ., Evanston, IL (United States). Biomedical Engineering Dept., Chemistry of Life Processes Inst.; Northwestern Univ., Evanston, IL (United States). Dept. of Chemistry, Dept. of Chemical and Biological Engineering, and the Robert H. Lurie Comprehensive Cancer Center

Material systems that can be used to flexibly and precisely define the chemical nature and molecular arrangement of a surface would be invaluable for the control of complex biointerfacial interactions. For example, progress in antifouling polymer biointerfaces that prevents nonspecific protein adsorption and cell attachment, which can significantly improve the performance of an array of biomedical and industrial applications, is hampered by a lack of chemical models to identify the molecular features conferring their properties. Poly(N-substituted glycine) “peptoids” are peptidomimetic polymers that can be conveniently synthesized with specific monomer sequences and chain lengths, and are presented as a versatile platform for investigating the molecular design of antifouling polymer brushes. Zwitterionic antifouling polymer brushes have captured significant recent attention, and a targeted library of zwitterionic peptoid brushes with different charge densities, hydration, separations between charged groups, chain lengths, and grafted chain densities, is quantitatively evaluated for their antifouling properties through a range of protein adsorption and cell attachment assays. Specific zwitterionic brush designs are found to give rise to distinct but subtle differences in properties. In conclusion, the results also point to the dominant roles of the grafted chain density and chain length in determining the performance of antifouling polymer brushes.

View Accepted Manuscript (DOE)

Research Organization:: Northwestern Univ., Evanston, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 1343092

Journal Information:: Advanced Materials Interfaces, Journal Name: Advanced Materials Interfaces Journal Issue: 1 Vol. 2; ISSN 2196-7350

Publisher:: Wiley-VCHCopyright Statement

Country of Publication:: United States

Language:: English

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