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Title: Distribution of iron oxide core-titanium dioxide shell nanoparticles in VX2 tumor bearing rabbits introduced by two different delivery modalities

Journal Article · · Nanomaterials
DOI:https://doi.org/10.3390/nano6080143· OSTI ID:1341018
 [1];  [2];  [3];  [2];  [2];  [2];  [2];  [2];  [2];  [4];  [4];  [4];  [5];  [2];  [2];  [2];  [2]
  1. Northwestern Univ., Chicago, IL (United States); Alexandria Univ., Alexandria (Egypt)
  2. Northwestern Univ., Chicago, IL (United States)
  3. Alexandria Univ., Alexandria (Egypt)
  4. Argonne National Lab. (ANL), Argonne, IL (United States)
  5. Vanderbilt Univ. School of Medicine, Nashville, TN (United States)
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This work compares intravenous (IV) versus fluoroscopy-guided transarterial intra-catheter (IC) delivery of iron oxide core-titanium dioxide shell nanoparticles (NPs) in vivo in VX2 model of liver cancer in rabbits. NPs coated with glucose and decorated with a peptide sequence from cortactin were administered to animals with developed VX2 liver cancer. Two hours after NPs delivery tumors, normal liver, kidney, lung and spleen tissues were harvested and used for a series on histological and elemental analysis tests. Quantification of NPs in tissues was done both by bulk inductively coupled plasma mass spectrometry (ICP-MS) analysis and by hard X-ray fluorescence microscopy. Both IV and IC NPs injection are feasible modalities for delivering NPs to VX2 liver tumors with comparable tumor accumulation. It is possible that this is an outcome of the fact that VX2 tumors are highly vascularized and hemorrhagic, and therefore enhanced permeability and retention (EPR) plays the most significant role in accumulation of nanoparticles in tumor tissue. It is, however, interesting to note that IV delivery led to increased sequestration of NPs by spleen and normal liver tissue, while IC delivery lead to more NP positive Kupffer cells. Furthermore, this difference is most likely a direct outcome of blood flow dynamics. Armed with this knowledge about nanoparticle delivery, we plan to test them as radiosensitizers in the future.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH); U.S. Army Research Laboratory, U.S. Army Research Office (ARO)
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1341018
Journal Information:
Nanomaterials, Vol. 6, Issue 8; ISSN 2079-4991
Publisher:
MDPICopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 6 works
Citation information provided by
Web of Science

References (27)

An essential role for cortactin in the modulation of the potassium channel Kv1.2 journal October 2007
Embolization of liver tumors: Past, present and future journal January 2012
The roles of K+ channels in cancer journal December 2013
Efficient drug-delivery using magnetic nanoparticles — biodistribution and therapeutic effects in tumour bearing rabbits journal October 2013
Methods for assessing DNA hybridization of peptide nucleic acid–titanium dioxide nanoconjugates journal December 2008
Biology of TiO2–oligonucleotide nanocomposites journal April 2003
A Study of Embolizing Materials for Chemo-embolization Therapy of Hepatocellular Carcinoma: Effects of Particle Size and Dose on Chitin-Containing cis-Diamminedichloroplatinum(II) Albumin Microsphere Antitumor Activity in VX2 Hepatic Tumor Model Rabbits. journal January 1994
Intraprocedural diffusion-weighted PROPELLER MRI to guide percutaneous biopsy needle placement within rabbit VX2 liver tumors journal August 2009
Comparison of Transcatheter Intraarterial Perfusion MR Imaging and Fluorescent Microsphere Perfusion Measurements during Transcatheter Arterial Embolization of Rabbit Liver Tumors journal October 2007
Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group journal September 2011
Global Cancer Statistics, 2002 journal March 2005
Epidermal Growth Factor Receptor Targeted Nuclear Delivery and High-Resolution Whole Cell X-ray Imaging of Fe 3 O 4 @TiO 2 Nanoparticles in Cancer Cells journal November 2013
DNA−TiO 2 Nanoconjugates Labeled with Magnetic Resonance Contrast Agents journal December 2007
Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells journal April 2011
Labeling TiO 2 Nanoparticles with Dyes for Optical Fluorescence Microscopy and Determination of TiO 2 -DNA Nanoconjugate Stability journal June 2009
Comparison of Two Different Methods for Inoculating VX2 Tumors in Rabbit Livers and Hind Limbs journal June 2008
NCI's provocative questions on cancer: some answers to ignite discussion journal December 2011
Liver Tumors: Monitoring Embolization in Rabbits with VX2 Tumors—Transcatheter Intraarterial First-Pass Perfusion MR Imaging journal October 2007
MR Tracking of Iron-labeled Glass Radioembolization Microspheres during Transcatheter Delivery to Rabbit VX2 Liver Tumors: Feasibility Study journal December 2008
Comparison between intravenous and intraarterial contrast injections for dynamic 3D MRI of liver tumors in the VX2 rabbit model journal January 2006
Intracellular Distribution of TiO 2 −DNA Oligonucleotide Nanoconjugates Directed to Nucleolus and Mitochondria Indicates Sequence Specificity journal March 2007
X-Ray Fluorescence Microscopy for Investigation of Archival Tissues journal January 2012
Real-time MRI Monitoring of Transcatheter Hepatic Artery Contrast Agent Delivery in Rabbits1 journal October 2005
Cytotoxicity and DNA cleavage with core–shell nanocomposites functionalized by a KH domain DNA binding peptide journal January 2013
Gadolinium-conjugated TiO2-DNA oligonucleotide nanoconjugates show prolonged intracellular retention period and T1-weighted contrast enhancement in magnetic resonance images journal September 2008
Titanium Dioxide Nanoparticles Assembled by dna Molecules Hybridization and Loading of dna Interacting Proteins journal February 2008
Nanocarriers Enhance Doxorubicin Uptake in Drug-Resistant Ovarian Cancer Cells journal December 2011

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MRI-guided interventional natural killer cell delivery for liver tumor treatment journal March 2018

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Related Subjects

36 MATERIALS SCIENCE
core–shell nanoparticle
rabbit VX2 liver cancer model
transarterial intra-catheter delivery