FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

Dhondt, Ineke; Petyuk, Vladislav A.; Cai, Huaihan; Vandemeulebroucke, Lieselot; Vierstraete, Andy; Smith, Richard D.; Depuydt, Geert; Braeckman, Bart P.

doi:10.1016/j.celrep.2016.07.088

Title: FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

Journal Article · Thu Sep 01 00:00:00 EDT 2016 · Cell Reports

DOI:https://doi.org/10.1016/j.celrep.2016.07.088· OSTI ID:1340775

Dhondt, Ineke; Petyuk, Vladislav A.; Cai, Huaihan; Vandemeulebroucke, Lieselot; Vierstraete, Andy; Smith, Richard D.; Depuydt, Geert; Braeckman, Bart P.

Cellular protein quality can be maintained by proteolytic elimination of damaged proteins and replacing them with newly synthesized copies, a process called protein turnover (Ward, 2000). Protein turnover rates have been estimated using SILAC (stable isotope labeling by amino acids in cell culture) in prokaryotes and eukaryotes. The last decade has witnessed a growing interest in the analysis of whole-organism proteome dynamics in metazoans using the same approach (Claydon and Beynon, 2012). In recent work, SILAC was applied to monitor protein synthesis throughout life in adult Caenorhabditis elegans (Vukoti et al., 2015) and to investigate food intake (Gomez-Amaro et al., 2015

Cite

Export

Save

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC05-76RL01830

OSTI ID:: 1340775

Report Number(s):: PNNL-SA-121059; 48135; 453040220

Journal Information:: Cell Reports, Vol. 16, Issue 11; ISSN 2211-1247

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

References (74)

The Effect of Long Term Calorie Restriction on in Vivo Hepatic Proteostatis: A Novel Combination of Dynamic and Quantitative Proteomics Price, John C.; Khambatta, Cyrus F.; Li, Kelvin W. Molecular & Cellular Proteomics, Vol. 11, Issue 12 https://doi.org/10.1074/mcp.m112.021204	journal	December 2012
Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16 McElwee, Joshua; Bubb, Kerry; Thomas, James H. Aging Cell, Vol. 2, Issue 2 https://doi.org/10.1046/j.1474-9728.2003.00043.x	journal	April 2003
A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans Hansen, Malene; Chandra, Abha; Mitic, Laura L. PLoS Genetics, Vol. 4, Issue 2 https://doi.org/10.1371/journal.pgen.0040024	journal	February 2008
A metabolic signature of long life in Caenorhabditis elegans Fuchs, Silke; Bundy, Jacob G.; Davies, Sarah K. BMC Biology, Vol. 8, Issue 1 https://doi.org/10.1186/1741-7007-8-14	journal	January 2010
Total human body protein synthesis in relation to protein requirements at various ages Young, Vernon R.; Steffee, William P.; Pencharz, Paul B. Nature, Vol. 253, Issue 5488 https://doi.org/10.1038/253192a0	journal	January 1975
The Lysosomal v-ATPase-Ragulator Complex Is a Common Activator for AMPK and mTORC1, Acting as a Switch between Catabolism and Anabolism Zhang, Chen-Song; Jiang, Bin; Li, Mengqi Cell Metabolism, Vol. 20, Issue 3 https://doi.org/10.1016/j.cmet.2014.06.014	journal	September 2014
C. elegans ortholog of mammalian Ku70 interacts with insulin‐like signaling to modulate stress resistance and life span McColl, Gawain; Vantipalli, Maithili C.; Lithgow, Gordon J. The FASEB Journal, Vol. 19, Issue 12 https://doi.org/10.1096/fj.04-2447fje	journal	July 2005
ProteomeXchange provides globally coordinated proteomics data submission and dissemination Vizcaíno, Juan A.; Deutsch, Eric W.; Wang, Rui Nature Biotechnology, Vol. 32, Issue 3 https://doi.org/10.1038/nbt.2839	journal	March 2014
Disruption of insulin signalling preserves bioenergetic competence of mitochondria in ageing Caenorhabditis elegans Brys, Kristel; Castelein, Natascha; Matthijssens, Filip BMC Biology, Vol. 8, Issue 1 https://doi.org/10.1186/1741-7007-8-91	journal	January 2010
Inhibition of mRNA translation extends lifespan in Caenorhabditis elegans Pan, Kally Z.; Palter, Julia E.; Rogers, Aric N. Aging Cell, Vol. 6, Issue 1 https://doi.org/10.1111/j.1474-9726.2006.00266.x	journal	February 2007
Widespread Proteome Remodeling and Aggregation in Aging C. elegans Walther, Dirk M.; Kasturi, Prasad; Zheng, Min Cell, Vol. 161, Issue 4 https://doi.org/10.1016/j.cell.2015.03.032	journal	May 2015
Regulation of Life-Span by Germ-Line Stem Cells in Caenorhabditis elegans Arantes-Oliveira, N. Science, Vol. 295, Issue 5554 https://doi.org/10.1126/science.1065768	journal	January 2002
Lysosomal Acidification Mechanisms Mindell, Joseph A. Annual Review of Physiology, Vol. 74, Issue 1 https://doi.org/10.1146/annurev-physiol-012110-142317	journal	March 2012
Increased Protein Stability and Decreased Protein Turnover in the Caenorhabditis elegans Ins/IGF-1 daf-2 Mutant Depuydt, Geert; Shanmugam, Nilesh; Rasulova, Madina The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, Vol. 71, Issue 12 https://doi.org/10.1093/gerona/glv221	journal	February 2016
Protein Synthesis Is a Novel Determinant of Aging in Caenorhabditis elegans Syntichaki, P.; Troulinaki, K.; Tavernarakis, N. Annals of the New York Academy of Sciences, Vol. 1119, Issue 1 https://doi.org/10.1196/annals.1404.001	journal	November 2007
Protein turnover plays a key role in aging Ryazanov, Alexey G.; Nefsky, Bradley S. Mechanisms of Ageing and Development, Vol. 123, Issue 2-3 https://doi.org/10.1016/S0047-6374(01)00337-2	journal	January 2002
Quantitative In Vivo Redox Sensors Uncover Oxidative Stress as an Early Event in Life Knoefler, Daniela; Thamsen, Maike; Koniczek, Martin Molecular Cell, Vol. 47, Issue 5 https://doi.org/10.1016/j.molcel.2012.06.016	journal	September 2012
Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease Visscher, Marieke; De Henau, Sasha; Wildschut, Mattheus H. E. Cell Reports, Vol. 16, Issue 11 https://doi.org/10.1016/j.celrep.2016.08.025	journal	September 2016
DAF-2 pathway mutations and food restriction in aging Caenorhabditis elegans differentially affect metabolism Houthoofd, Koen; Braeckman, Bart P.; Lenaerts, Isabelle Neurobiology of Aging, Vol. 26, Issue 5 https://doi.org/10.1016/j.neurobiolaging.2004.06.011	journal	May 2005
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans Palikaras, Konstantinos; Lionaki, Eirini; Tavernarakis, Nektarios Nature, Vol. 521, Issue 7553 https://doi.org/10.1038/nature14300	journal	April 2015
NIH Image to ImageJ: 25 years of image analysis Schneider, Caroline A.; Rasband, Wayne S.; Eliceiri, Kevin W. Nature Methods, Vol. 9, Issue 7 https://doi.org/10.1038/nmeth.2089	journal	June 2012
The creatine kinase system and pleiotropic effects of creatine Wallimann, Theo; Tokarska-Schlattner, Malgorzata; Schlattner, Uwe Amino Acids, Vol. 40, Issue 5 https://doi.org/10.1007/s00726-011-0877-3	journal	March 2011
TM4: A Free, Open-Source System for Microarray Data Management and Analysis Saeed, A. I.; Sharov, V.; White, J. BioTechniques, Vol. 34, Issue 2 https://doi.org/10.2144/03342mt01	journal	February 2003
Metabolic Youth in Middle Age: Predicting Aging in Caenorhabditis elegans Using Metabolomics Davies, Sarah K.; Bundy, Jacob G.; Leroi, Armand M. Journal of Proteome Research, Vol. 14, Issue 11 https://doi.org/10.1021/acs.jproteome.5b00442	journal	October 2015
Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans Van Raamsdonk, Jeremy M.; Hekimi, Siegfried PLoS Genetics, Vol. 5, Issue 2 https://doi.org/10.1371/journal.pgen.1000361	journal	February 2009
Measuring Food Intake and Nutrient Absorption in Caenorhabditis elegans Gomez-Amaro, Rafael L.; Valentine, Elizabeth R.; Carretero, Maria Genetics, Vol. 200, Issue 2 https://doi.org/10.1534/genetics.115.175851	journal	April 2015
Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects Karunadharma, Pabalu P.; Basisty, Nathan; Dai, Dao‐Fu Aging Cell, Vol. 14, Issue 4 https://doi.org/10.1111/acel.12317	journal	March 2015
Signals from the reproductive system regulate the lifespan of C. elegans Hsin, Honor; Kenyon, Cynthia Nature, Vol. 399, Issue 6734 https://doi.org/10.1038/20694	journal	May 1999
Life span and stress resistance of Caenorhabditis elegans are differentially affected by glutathione transferases metabolizing 4-hydroxynon-2-enal Ayyadevara, S.; Dandapat, A.; Singh, S. Mechanisms of Ageing and Development, Vol. 128, Issue 2 https://doi.org/10.1016/j.mad.2006.11.025	journal	February 2007
Version 4.0 of PaxDb: Protein abundance data, integrated across model organisms, tissues, and cell-lines Wang, Mingcong; Herrmann, Christina J.; Simonovic, Milan PROTEOMICS, Vol. 15, Issue 18 https://doi.org/10.1002/pmic.201400441	journal	March 2015
LC–MS Proteomics Analysis of the Insulin/IGF-1-Deficient Caenorhabditis elegans daf-2(e1370) Mutant Reveals Extensive Restructuring of Intermediary Metabolism Depuydt, Geert; Xie, Fang; Petyuk, Vladislav A. Journal of Proteome Research, Vol. 13, Issue 4 https://doi.org/10.1021/pr401081b	journal	March 2014
Aging as an Event of Proteostasis Collapse Taylor, R. C.; Dillin, A. Cold Spring Harbor Perspectives in Biology, Vol. 3, Issue 5 https://doi.org/10.1101/cshperspect.a004440	journal	February 2011
Morphology and function of membrane-bound organelles Heald, Rebecca; Cohen-Fix, Orna Current Opinion in Cell Biology, Vol. 26 https://doi.org/10.1016/j.ceb.2013.10.006	journal	February 2014
C. elegans Germline-Deficient Mutants Respond to Pathogen Infection Using Shared and Distinct Mechanisms TeKippe, Michael; Aballay, Alejandro PLoS ONE, Vol. 5, Issue 7 https://doi.org/10.1371/journal.pone.0011777	journal	July 2010
Proteome Dynamics: Revisiting Turnover with a Global Perspective Claydon, Amy J.; Beynon, Robert Molecular & Cellular Proteomics, Vol. 11, Issue 12 https://doi.org/10.1074/mcp.o112.022186	journal	December 2012
Caenorhabditis elegans glp-4 Encodes a Valyl Aminoacyl tRNA Synthetase Rastogi, Suchita; Borgo, Ben; Pazdernik, Nanette G3 Genes\|Genomes\|Genetics, Vol. 5, Issue 12 https://doi.org/10.1534/g3.115.021899	journal	December 2015
Autophagy: molecular machinery for self-eating Yorimitsu, T.; Klionsky, D. J. Cell Death & Differentiation, Vol. 12, Issue S2 https://doi.org/10.1038/sj.cdd.4401765	journal	October 2005
Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways Shore, David E.; Carr, Christopher E.; Ruvkun, Gary PLoS Genetics, Vol. 8, Issue 7 https://doi.org/10.1371/journal.pgen.1002792	journal	July 2012
The effects of aging and chronic dietary restriction on whole body growth and protein turnover in the rat Lewis, Sheena E. M.; Goldspink, David F.; Phillips, John G. Experimental Gerontology, Vol. 20, Issue 5 https://doi.org/10.1016/0531-5565(85)90050-6	journal	January 1985
The daf‐2 gene network for longevity regulates oxidative stress resistance and Mn‐superoxide dismutase gene expression in Caenorhabditis elegans Honda, Yoko; Honda, Shuji The FASEB Journal, Vol. 13, Issue 11 https://doi.org/10.1096/fasebj.13.11.1385	journal	August 1999
Crystal structure of a central stalk subunit C and reversible association/dissociation of vacuole-type ATPase Iwata, M.; Imamura, H.; Stambouli, E. Proceedings of the National Academy of Sciences, Vol. 101, Issue 1 https://doi.org/10.1073/pnas.0305165101	journal	December 2003
A Measurable Increase in Oxidative Damage Due to Reduction in Superoxide Detoxification Fails to Shorten the Life Span of Long-Lived Mitochondrial Mutants of Caenorhabditis elegans Yang, Wen; Li, Jingjing; Hekimi, Siegfried Genetics, Vol. 177, Issue 4 https://doi.org/10.1534/genetics.107.080788	journal	December 2007
Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans Melendez, A. Science, Vol. 301, Issue 5638 https://doi.org/10.1126/science.1087782	journal	September 2003
A Long Noncoding RNA on the Ribosome Is Required for Lifespan Extension Essers, Paul B.; Nonnekens, Julie; Goos, Yvonne J. Cell Reports, Vol. 10, Issue 3 https://doi.org/10.1016/j.celrep.2014.12.029	journal	January 2015
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans Hansen, Malene; Taubert, Stefan; Crawford, Douglas Aging Cell, Vol. 6, Issue 1 https://doi.org/10.1111/j.1474-9726.2006.00267.x	journal	February 2007
Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics Krijgsveld, Jeroen; Ketting, René F.; Mahmoudi, Tokameh Nature Biotechnology, Vol. 21, Issue 8 https://doi.org/10.1038/nbt848	journal	July 2003
A C. elegans mutant that lives twice as long as wild type Kenyon, Cynthia; Chang, Jean; Gensch, Erin Nature, Vol. 366, Issue 6454 https://doi.org/10.1038/366461a0	journal	December 1993
Oxidative stress, aging and the proteasomal system Grune, Tilman Biogerontology, Vol. 1, Issue 1, p. 31-40 https://doi.org/10.1023/A:1010037908060	journal	January 2000
Differential Geometry Meets the Cell Marshall, Wallace F. Cell, Vol. 154, Issue 2 https://doi.org/10.1016/j.cell.2013.06.032	journal	July 2013
Evolutionary conservation of regulated longevity assurance mechanisms McElwee, Joshua J.; Schuster, Eugene; Blanc, Eric Genome Biology, Vol. 8, Issue 7 https://doi.org/10.1186/gb-2007-8-7-r132	journal	January 2007
Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans Doonan, R.; McElwee, J. J.; Matthijssens, F. Genes & Development, Vol. 22, Issue 23 https://doi.org/10.1101/gad.504808	journal	November 2008
Assessing metabolic activity in aging Caenorhabditis elegans: concepts and controversies: Assessing metabolic rate in aging C. elegans, B. P. Braeckman et al. Braeckman, Bart P.; Houthoofd, Koen; Vanfleteren, Jacques R. Aging Cell, Vol. 1, Issue 2 https://doi.org/10.1046/j.1474-9728.2002.00021.x	journal	November 2002
Opposed growth factor signals control protein degradation in muscles of Caenorhabditis elegans Szewczyk, Nathaniel J.; Peterson, Brant K.; Barmada, Sami J. The EMBO Journal, Vol. 26, Issue 4 https://doi.org/10.1038/sj.emboj.7601540	journal	February 2007
Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling Lin, Kui; Hsin, Honor; Libina, Natasha Nature Genetics, Vol. 28, Issue 2 https://doi.org/10.1038/88850	journal	June 2001
Alternative Perspectives on Aging in Caenorhabditis elegans : Reactive Oxygen Species or Hyperfunction? Gems, David; de la Guardia, Yila Antioxidants & Redox Signaling, Vol. 19, Issue 3 https://doi.org/10.1089/ars.2012.4840	journal	July 2013
Answering the ultimate question “What is the Proximal Cause of Aging?” Blagosklonny, Mikhail V. Aging, Vol. 4, Issue 12 https://doi.org/10.18632/aging.100525	journal	December 2012
Engineering of a monomeric green-to-red photoactivatable fluorescent protein induced by blue light Gurskaya, Nadya G.; Verkhusha, Vladislav V.; Shcheglov, Alexander S. Nature Biotechnology, Vol. 24, Issue 4 https://doi.org/10.1038/nbt1191	journal	March 2006
Revisiting the regulated secretory pathway: From frogs to human Vázquez-Martínez, Rafael; Díaz-Ruiz, Alberto; Almabouada, Farid General and Comparative Endocrinology, Vol. 175, Issue 1 https://doi.org/10.1016/j.ygcen.2011.08.017	journal	January 2012
Insulin/IGF‐1‐mediated longevity is marked by reduced protein metabolism Stout, Gerdine J.; Stigter, Edwin C. A.; Essers, Paul B. Molecular Systems Biology, Vol. 9, Issue 1 https://doi.org/10.1038/msb.2013.35	journal	January 2013
The Where, When, and How of Organelle Acidification by the Yeast Vacuolar H+-ATPase Kane, Patricia M. Microbiology and Molecular Biology Reviews, Vol. 70, Issue 1 https://doi.org/10.1128/MMBR.70.1.177-191.2006	journal	March 2006
Monitoring Newly Synthesized Proteins over the Adult Life Span of Caenorhabditis elegans Vukoti, Krishna; Yu, Xiaokun; Sheng, Quanhu Journal of Proteome Research, Vol. 14, Issue 3 https://doi.org/10.1021/acs.jproteome.5b00021	journal	February 2015
Stacked Endoplasmic Reticulum Sheets Are Connected by Helicoidal Membrane Motifs Terasaki, Mark; Shemesh, Tom; Kasthuri, Narayanan Cell, Vol. 154, Issue 2 https://doi.org/10.1016/j.cell.2013.06.031	journal	July 2013
Trehalose extends longevity in the nematode Caenorhabditis elegans: Trehalose extends longevity in C. elegans Honda, Yoko; Tanaka, Masashi; Honda, Shuji Aging Cell, Vol. 9, Issue 4 https://doi.org/10.1111/j.1474-9726.2010.00582.x	journal	June 2010
limma powers differential expression analyses for RNA-sequencing and microarray studies Ritchie, Matthew E.; Phipson, Belinda; Wu, Di Nucleic Acids Research, Vol. 43, Issue 7 https://doi.org/10.1093/nar/gkv007	journal	January 2015
The relentless effects of the aging process on protein turnover Ward, Walter F. Biogerontology, Vol. 1, Issue 3, p. 195-199 https://doi.org/10.1023/A:1010076818119	journal	January 2000
Two Pleiotropic Classes of daf-2 Mutation Affect Larval Arrest, Adult Behavior, Reproduction and Longevity in Caenorhabditis elegans Gems, David; Sutton, Amy J.; Sundermeyer, Mark L. Genetics, Vol. 150, Issue 1 https://doi.org/10.1093/genetics/150.1.129	journal	September 1998
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients Kaeberlein, M. Science, Vol. 310, Issue 5751 https://doi.org/10.1126/science.1115535	journal	November 2005
Synthesis, modifications, and turnover of proteins during aging Rattan, Suresh I. S. Experimental Gerontology, Vol. 31, Issue 1-2 https://doi.org/10.1016/0531-5565(95)02022-5	journal	January 1996
Substrate- and Isoform-Specific Proteome Stability in Normal and Stressed Cardiac Mitochondria Lau, Edward; Wang, Ding; Zhang, Jun Circulation Research, Vol. 110, Issue 9 https://doi.org/10.1161/circresaha.112.268359	journal	April 2012
Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy Sandri, Marco; Sandri, Claudia; Gilbert, Alex Cell, Vol. 117, Issue 3 https://doi.org/10.1016/s0092-8674(04)00400-3	journal	April 2004
Dynamic Changes of the Caenorhabditis elegans Proteome during Ontogenesis Assessed by Quantitative Analysis with ¹⁵ N Metabolic Labeling Geillinger, Kerstin E.; Kuhlmann, Katja; Eisenacher, Martin Journal of Proteome Research, Vol. 11, Issue 9 https://doi.org/10.1021/pr300385v	journal	August 2012
Reduced Insulin/Insulin-like Growth Factor-1 Signaling and Dietary Restriction Inhibit Translation but Preserve Muscle Mass in Caenorhabditis elegans Depuydt, Geert; Xie, Fang; Petyuk, Vladislav A. Molecular & Cellular Proteomics, Vol. 12, Issue 12 https://doi.org/10.1074/mcp.M113.027383	journal	September 2013
Shared Transcriptional Signature in Caenorhabditis elegans Dauer Larvae and Long-lived daf-2 Mutants Implicates Detoxification System in Longevity Assurance McElwee, Joshua J.; Schuster, Eugene; Blanc, Eric Journal of Biological Chemistry, Vol. 279, Issue 43 https://doi.org/10.1074/jbc.M406207200	journal	October 2004
Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans Murphy, Coleen T.; McCarroll, Steven A.; Bargmann, Cornelia I. Nature, Vol. 424, Issue 6946 https://doi.org/10.1038/nature01789	journal	June 2003

Cited By (9)

Nucleolar expansion and elevated protein translation in premature aging Buchwalter, Abigail; Hetzer, Martin W. Nature Communications, Vol. 8, Issue 1 https://doi.org/10.1038/s41467-017-00322-z	journal	August 2017
Accumulation of “Old Proteins” and the Critical Need for MS‐based Protein Turnover Measurements in Aging and Longevity Basisty, Nathan; Holtz, Anja; Schilling, Birgit PROTEOMICS, Vol. 20, Issue 5-6 https://doi.org/10.1002/pmic.201800403	journal	March 2020
hsp-16.2 chaperone biomarkers track physiological states of proteome dosage Burnaevskiy, Nikolay; Sands, Bryan; Yun, Soo https://doi.org/10.1101/431643	posted_content	September 2019
Proteome-wide Changes in Protein Turnover Rates in C. elegans Models of Longevity and Age-Related Disease Visscher, Marieke; De Henau, Sasha; Wildschut, Mattheus H. E. Cell Reports, Vol. 16, Issue 11 https://doi.org/10.1016/j.celrep.2016.08.025	journal	September 2016
Royalactin induces copious longevity via increased translation and proteasome activity in C. elegans Detienne, Giel; Van de Walle, Pieter; De Haes, Wouter https://doi.org/10.1101/421818	posted_content	September 2018
Immunohistochemical analysis reveals variations in proteasome tissue expression in C. elegans Mikkonen, Elisa; Haglund, Caj; Holmberg, Carina I. PLOS ONE, Vol. 12, Issue 8 https://doi.org/10.1371/journal.pone.0183403	journal	August 2017
Paradoxes of senolytics Blagosklonny, Mikhail V. Aging, Vol. 10, Issue 12 https://doi.org/10.18632/aging.101750	journal	December 2018
C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies Ezcurra, Marina; Benedetto, Alexandre; Sornda, Thanet Current Biology, Vol. 28, Issue 20 https://doi.org/10.1016/j.cub.2018.10.003	journal	October 2018
Lysine-Less Variants of Spinal Muscular Atrophy SMN and SMNΔ7 Proteins Are Degraded by the Proteasome Pathway Sánchez-Lanzas, Raúl; Castaño, José G. International Journal of Molecular Sciences, Vol. 18, Issue 12 https://doi.org/10.3390/ijms18122667	journal	December 2017

Similar Records

FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

Journal Article · Thu Sep 01 00:00:00 EDT 2016 · Cell Reports · OSTI ID:1340775

Dhondt, Ineke; Petyuk, Vladislav A.; Cai, Huaihan; +5 more

NMR Structure of Conserved Eukaryotic Protein ZK652.3 from C. elegans: a Ubiquitin-like Fold

Journal Article · Sun Sep 01 00:00:00 EDT 2002 · Proteins: Structure, Function, and Genetics · OSTI ID:1340775

Cort, John R; Chiang, Yiwen; Zheng, Deyou; +2 more

Changes of Protein Turnover in Aging Caenorhabditis elegans

Journal Article · Fri Sep 01 00:00:00 EDT 2017 · Molecular and Cellular Proteomics · OSTI ID:1340775

Dhondt, Ineke; Petyuk, Vladislav A.; Bauer, Sophie; +4 more

Related Subjects

Environmental Molecular Sciences Laboratory

Title: FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans

Citation Formats

References (74)

Cited By (9)

Similar Records

Related Subjects