Semiconductor nanocrystal probes for biological applications and process for making and using such probes

Weiss, Shimon; Bruchez, Marcel; Alivisatos, Paul A.

Title: Semiconductor nanocrystal probes for biological applications and process for making and using such probes

Patent · Tue Dec 27 00:00:00 EST 2016

OSTI ID:1337624

Weiss, Shimon; Bruchez, Marcel; Alivisatos, Paul A.

A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

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Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC03-76SF00098

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Number(s):: 9,530,928

Application Number:: 14/103,725

OSTI ID:: 1337624

Resource Relation:: Patent File Date: 2013 Dec 11

Country of Publication:: United States

Language:: English

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