Several loci at chromosome 9p are involved in early and late stages of growth of cutaneous malignant melanoma
- Cancer Research Institute, Barcelona (France)
- Cancer Reseach Institute, Barcelona (France); and others
To study the inactivation of a possible tumor suppressor gene at chromosome 9p associated with the development and progression of cutaneous malignant melanoma (CMM), we have analyzed 12 microsatellite markers in 54 paired tumors and normal tissues. Forty-six percent of the tumors (corresponding to 52% of patients) showed loss of heterozygosity (LOH) for at least one marker. The smallest deleted region included markers D9S126, D9S265 and D9S259, spanning 5 centiMorgans of chromosome 9p21. Forty-two percent of the metastasic tumors and 50% of the primary tumors, including two in situ CMM, showed 9p21 deletions. Tumors with the worst prognoses showed larger deletions at 9p, ({chi}{sup 2} = 4.16, p < 0.04), and three cases showed two non-contiguous regions deleted, one telomeric to IFNA and the other centromeric. The presence of large and non-contiguous deletions, in the cases with the worst prognoses, suggests the existence of more than one tumor suppressor gene at 9p involved in the predisposition to, and progression of, malignant melanoma, outside the region of the recently identified p16 gene (MTS1), which has been found deleted in about 60% of melanoma cell lines.
- OSTI ID:
- 133559
- Report Number(s):
- CONF-941009-; ISSN 0002-9297; TRN: 95:005313-0287
- Journal Information:
- American Journal of Human Genetics, Vol. 55, Issue Suppl.3; Conference: 44. annual meeting of the American Society of Human Genetics, Montreal (Canada), 18-22 Oct 1994; Other Information: PBD: Sep 1994
- Country of Publication:
- United States
- Language:
- English
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