Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles

Chambers, Mariah; Mallory, Stewart Anthony; Malone, Heather; Gao, Yuan; Anthony, Stephen M.; Yi, Yi; Cacciuto, Angelo; Yu, Yan

doi:10.1039/c6sm02171a

Lipid membrane-assisted condensation and assembly of amphiphilic Janus particles

Journal Article · Thu Dec 31 23:00:00 EST 2015 · Soft Matter

DOI:https://doi.org/10.1039/c6sm02171a· OSTI ID:1334497

Chambers, Mariah ^[1]; Mallory, Stewart Anthony ^[2]; Malone, Heather ^[1]; Gao, Yuan ^[1]; Anthony, Stephen M. ^[3]; Yi, Yi ^[1]; Cacciuto, Angelo ^[2]; Yu, Yan ^[1]

Indiana Univ., Bloomington, IN (United States)
Columbia Univ., Broadway, NY (United States)
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Amphiphilic Janus particles self-assemble into complex metastructures, but little is known about how their assembly might be modified by weak interactions with a nearby biological membrane surface. Here, we report an integrated experimental and molecular dynamics simulation study to investigate the self-assembly of amphiphilic Janus particles on a lipid membrane. We created an experimental system in which Janus particles are allowed to self-assemble in the same medium where zwitterionic lipids form giant unilamellar vesicles (GUVs). Janus particles spontaneously concentrated on the inner leaflet of the GUVs. They exhibited biased orientation and heterogeneous rotational dynamics as revealed by single particle rotational tracking. The combined experimental and simulation results show that Janus particles concentrate on the lipid membranes due to weak particle–lipid attraction, whereas the biased orientation of particles is driven predominantly by inter-particle interactions. Furthermore, this study demonstrates the potential of using lipid membranes to influence the self-assembly of Janus particles.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC04-94AL85000

OSTI ID:: 1334497

Report Number(s):: SAND--2016-12074J; 649523

Journal Information:: Soft Matter, Journal Name: Soft Matter Journal Issue: 45 Vol. 12; ISSN SMOABF; ISSN 1744-683X

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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Vesicle constriction by rings of Janus nanoparticles and aggregates of curved proteins Bahrami, Arash; Bahrami, Amir Houshang Nanotechnology, Vol. 30, Issue 34 https://doi.org/10.1088/1361-6528/ab1ed5	journal	May 2019

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