Aragonite-Associated Mollusk Shell Protein Aggregates To Form Mesoscale “Smart” Hydrogels

Perovic, Iva; Davidyants, Anastasia; Evans, John Spencer

doi:10.1021/acsomega.6b00236

Title: Aragonite-Associated Mollusk Shell Protein Aggregates To Form Mesoscale “Smart” Hydrogels

Journal Article · Thu Nov 10 00:00:00 EST 2016 · ACS Omega

DOI:https://doi.org/10.1021/acsomega.6b00236· OSTI ID:1331710

Perovic, Iva ^[1]; Davidyants, Anastasia ^[1]; Evans, John Spencer ^[1]

Center for Skeletal Biology and Craniofacial Medicine, Laboratory for Chemical Physics, New York University College of Dentistry, New York, New York 10010, United States

In the mollusk shell there exists a framework silk fibroin-polysaccharide hydrogel coating around nacre aragonite tablets, and this coating facilitates the synthesis and organization of mineral nanoparticles into mesocrystals. In this report, we identify that a protein component of this coating, n16.3, is a hydrogelator. Due to the presence of intrinsic disorder, aggregation-prone regions, and nearly equal balance of anionic and cationic side chains, this protein assembles to form porous mesoscale hydrogel particles in solution and on mica surfaces. These hydrogel particles change their dimensionality, organization, and internal structure in response to pH and ions, particularly Ca(II), which indicates that these behave as ion-responsive or “smart” hydrogels. Thus, in addition to silk fibroins, the gel phase of the mollusk shell nacre framework layer may actually consist of several framework hydrogelator proteins, such as n16.3, which can promote mineral nanoparticle organization and assembly during the nacre biomineralization process and also serve as a model system for designing ion-responsive, composite, and smart hydrogels.

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Research Organization:: New York Univ. (NYU), NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: FG02-03ER46099

OSTI ID:: 1331710

Alternate ID(s):: OSTI ID: 1334182

Journal Information:: ACS Omega, Journal Name: ACS Omega Vol. 1 Journal Issue: 5; ISSN 2470-1343

Publisher:: American Chemical SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 13 works

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