skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Methods of treating Parkinson's disease using viral vectors

Abstract

Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.

Inventors:
;
Publication Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1332285
Patent Number(s):
9,492,415
Application Number:
13/647,155
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
AC03-76SF00098; AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Oct 08
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Bankiewicz, Krystof, and Cunningham, Janet. Methods of treating Parkinson's disease using viral vectors. United States: N. p., 2016. Web.
Bankiewicz, Krystof, & Cunningham, Janet. Methods of treating Parkinson's disease using viral vectors. United States.
Bankiewicz, Krystof, and Cunningham, Janet. Tue . "Methods of treating Parkinson's disease using viral vectors". United States. https://www.osti.gov/servlets/purl/1332285.
@article{osti_1332285,
title = {Methods of treating Parkinson's disease using viral vectors},
author = {Bankiewicz, Krystof and Cunningham, Janet},
abstractNote = {Methods of delivering viral vectors, particularly recombinant adeno-associated virus (rAAV) virions, to the central nervous system (CNS) using convection enhanced delivery (CED) are provided. The rAAV virions include a nucleic acid sequence encoding a therapeutic polypeptide. The methods can be used for treating CNS disorders such as for treating Parkinson's Disease.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {11}
}

Patent:

Save / Share:

Works referenced in this record:

Practical Aspects of the Development ofex Vivoandin VivoGene Therapy for Parkinson's Disease
journal, March 1997

  • Bankiewicz, Krzysztof S.; Leff, Stuart E.; Nagy, Dea
  • Experimental Neurology, Vol. 144, Issue 1
  • DOI: 10.1006/exnr.1996.6401

Application of Gene Therapy for Parkinson's Disease: Nonhuman Primate Experience
book, January 1997


Adeno-associated virus vectors
journal, October 1992


Ligand-targeted receptor-mediated vectors for gene delivery
journal, January 1998


A novel MPTP primate model of Parkinson's disease: neurochemical and clinical changes
journal, September 1998


Total synthesis of a human leukocyte interferon gene
journal, August 1981

  • Edge, Michael D.; Greene, April R.; Heathcliffe, Gillian R.
  • Nature, Vol. 292, Issue 5825
  • DOI: 10.1038/292756a0

Prospects and problems of gene therapy: an update
journal, October 2001


Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5
journal, July 1977


Convection-Enhanced Delivery of Adeno-Associated Virus Type 2 (AAV2) into the Striatum and Transport of AAV2 Within Monkey Brain
journal, March 2006

  • Hadaczek, Piotr; Kohutnicka, Malgorzata; Krauze, Michal T.
  • Human Gene Therapy, Vol. 17, Issue 3
  • DOI: 10.1089/hum.2006.17.291

Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector
journal, January 1999

  • Herzog, Roland W.; Yang, Edmund Y.; Couto, Linda B.
  • Nature Medicine, Vol. 5, Issue 1
  • DOI: 10.1038/4743

Prospects for the Use of Adeno-Associated Virus as a Vector for Human Gene Therapy
journal, July 1994


Mechanism of MPTP toxicity: more answers, more questions
journal, January 1985


Effect of ischemic cerebral volume changes on behavior
journal, August 1997


l-Dopa and Dopamine-Producing Gene Cassettes for Gene Therapy Approaches to Parkinson's Disease
journal, March 1997

  • Moffat, Mark; Harmon, Steve; Haycock, John
  • Experimental Neurology, Vol. 144, Issue 1
  • DOI: 10.1006/exnr.1996.6390

Gene Therapy in the United States: A Five-Year Status Report
journal, September 1996


Viral Gene Delivery Selectively Restores Feeding and Prevents Lethality of Dopamine-Deficient Mice
journal, January 1999


Gene therapy - promises, problems and prospects
journal, September 1997

  • Verma, Inder M.; Somia, Nikunj
  • Nature, Vol. 389, Issue 6648
  • DOI: 10.1038/38410

Adeno-associated virus vector-mediated transduction in the cat brain
journal, September 2003

  • Vite, Charles H.; Passini, Marco A.; Haskins, Mark E.
  • Gene Therapy, Vol. 10, Issue 22
  • DOI: 10.1038/sj.gt.3302087

Gene Transfer by Adeno-Associated Virus Vectors into the Central Nervous System
journal, March 1997

  • Xiao, Xiao; Li, Juan; McCown, Thomas J.
  • Experimental Neurology, Vol. 144, Issue 1
  • DOI: 10.1006/exnr.1996.6396