Advances in imaging secondary ion mass spectrometry for biological samples

Boxer, Steven G.; Kraft, Mary L.; Weber, Peter K.

doi:10.1146/annurev.biophys.050708.133634

Advances in imaging secondary ion mass spectrometry for biological samples

Journal Article · Tue Dec 16 00:00:00 EST 2008 · Annual Review of Biophysics

DOI:https://doi.org/10.1146/annurev.biophys.050708.133634· OSTI ID:1305904

Boxer, Steven G. ^[1]; Kraft, Mary L. ^[2]; Weber, Peter K. ^[3]

Stanford Univ., Stanford, CA (United States). Dept. of Chemistry
Univ. of Illinois, Urbana-Champaign, Urbana, IL (United States). Dept of Chemical and Biomolecular Engineering
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States). Glenn T. Seaborg Institute

Imaging mass spectrometry combines the power of mass spectrometry to identify complex molecules based on mass with sample imaging. Recent advances in secondary ion mass spectrometry have improved sensitivity and spatial resolution, so that these methods have the potential to bridge between high-resolution structures obtained by X-ray crystallography and cyro-electron microscopy and ultrastructure visualized by conventional light microscopy. Following background information on the method and instrumentation, we address the key issue of sample preparation. Because mass spectrometry is performed in high vacuum, it is essential to preserve the lateral organization of the sample while removing bulk water, and this has been a major barrier for applications to biological systems. Furthermore, recent applications of imaging mass spectrometry to cell biology, microbial communities, and biosynthetic pathways are summarized briefly, and studies of biological membrane organization are described in greater depth.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC52-07NA27344

OSTI ID:: 1305904

Report Number(s):: LLNL-JRNL--408214

Journal Information:: Annual Review of Biophysics, Journal Name: Annual Review of Biophysics Journal Issue: 1 Vol. 38; ISSN 1936-122X

Publisher:: Annual ReviewsCopyright Statement

Country of Publication:: United States

Language:: English

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