Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases

Huang, Edmond Y.; Inoue, Takuya; Leone, Vanessa A.; Dalal, Sushila; Touw, Ketrija; Wang, Yunwei; Musch, Mark W.; Theriault, Betty; Higuchi, Kazuhide; Donovan, Sharon; Gilbert, Jack; Chang, Eugene B.

doi:10.1097/mib.0000000000000332

Using Corticosteroids to Reshape the Gut Microbiome: Implications for Inflammatory Bowel Diseases

Journal Article · Fri May 01 04:00:00 EDT 2015 · Inflammatory Bowel Diseases

DOI:https://doi.org/10.1097/mib.0000000000000332· OSTI ID:1280876

Huang, Edmond Y. ^[1]; Inoue, Takuya ^[2]; Leone, Vanessa A. ^[1]; Dalal, Sushila ^[1]; Touw, Ketrija ^[1]; Wang, Yunwei ^[1]; Musch, Mark W. ^[1]; Theriault, Betty ^[1]; Higuchi, Kazuhide ^[2]; Donovan, Sharon ^[3]; Gilbert, Jack ^[4]; Chang, Eugene B. ^[1]

Univ. of Chicago, IL (United States). Knapp Center for Biomedical Discovery, Dept. of Medicine
Osaka Medical College, Takatsuki, Osaka (Japan). 2nd Dept. of Internal Medicine
Univ. of Illinois, Urbana, IL (United States). Dept. of Food Science and Human Nutrition
Argonne National Lab. (ANL), Argonne, IL (United States). Biosciences Division; Univ. of Chicago, IL (United States). Dept. of Ecology and Evolution; Marine Biological Laboratory, Woods Hole, MA (United States); Zhejiang Univ., Hangzhou (China). College of Environmental and Resource Sciences

Introduction—Commensal gut microbiota play an important role in regulating metabolic and inflammatory conditions. Reshaping intestinal microbiota through pharmacologic means may be a viable treatment option. Here we sought to delineate the functional characteristics of glucocorticoid-mediated alterations on gut microbiota and their subsequent repercussions on host mucin regulation and colonic inflammation. Methods—Adult male C57Bl/6 mice, germ-free (GF), Muc2-heterozygote (±), or Muc2-knockout (-/-) were injected with dexamethasone, a synthetic glucocorticoid, for four weeks. Fecal samples were collected for gut microbiota analysis via 16S rRNA T-RFLP and amplicon sequencing. Intestinal mucosa was collected for mucin gene expression studies. GF mice were conventionalized with gut microbes from treated- and non-treated groups to determine their functional capacities in recipient hosts. Results—Exposure to DEX in WT mice led to substantial shifts in gut microbiota over a four-week period. Furthermore, a significant down-regulation of colonic Muc2 gene expression was observed after treatment. Muc2-knockout mice harbored a pro-inflammatory environment of gut microbes, characterized by the increase or decrease in prevalence of specific microbiota populations such as Clostridiales and Lactobacillaceae, respectively. This colitogenic phenotype was transmissible to IL10-knockout (IL10-KO) mice, a genetically susceptible model of colonic inflammatory disorders. Microbiota from donors pre-treated with DEX, however, ameliorated symptoms of inflammation. We conclude that commensal gut bacteria may be a key mediator of the anti-inflammatory effects observed in the large intestine after GC exposure. These findings underscore the notion that intestinal microbes comprise a “microbial organ” essential for host physiology that can be targeted by therapeutic approaches to restore intestinal homeostasis.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE; National Inst. of Health (NIH)

OSTI ID:: 1280876

Journal Information:: Inflammatory Bowel Diseases, Journal Name: Inflammatory Bowel Diseases Journal Issue: 5 Vol. 21; ISSN 1078-0998

Publisher:: Crohn's & Colitis Foundation of AmericaCopyright Statement

Country of Publication:: United States

Language:: English

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