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Title: Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

Journal Article · · Journal of Membrane Biology
 [1];  [2];  [3];  [4];  [5];  [6];  [7];  [3];  [8];  [9];  [10];  [1];  [5];  [11];  [12];  [13];  [8];  [14];  [15];  [5] more »;  [3];  [16];  [17];  [7];  [18];  [19];  [20];  [21];  [22] « less
  1. Academy of Athens (Greece)
  2. Univ. of California, Davis, CA (United States); RMIT Univ., Melbourne (Australia)
  3. Univ. of California, Irvine, CA (United States)
  4. Univ. of Nice Sophia Antipolis and French National Center for Scientific Research (France)
  5. Zuse Inst. of Berlin (Germany)
  6. Rutgers Univ., Camden, NJ (United States)
  7. Univ. College, Dublin (Ireland)
  8. Temple Univ., Philadelphia, PA (United States)
  9. Univ. of Granada (Spain)
  10. Linnaeus Univ., Kalmar (Sweden)
  11. IBPC and CNRS, Paris (France)
  12. Univ. of Lorraine, Nancy (France); Lomonosov Moscow State Univ. (Russia)
  13. Univ. of Athens (Greece)
  14. Univ. of Southampton (United Kingdom)
  15. Univ. of Alberta, Edmonton, AB (Canada)
  16. Pompeu Fabra Univ., Barcelona (Spain)
  17. Univ. of Lorraine and CNRS, Nancy (France)
  18. Univ. of Nice Sophia Antipolis and French National Center for Scientific Research (France)
  19. Johns Hopkins Univ., Baltimore, MD (United States)
  20. Univ. of Cambridge (United Kingdom)
  21. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  22. Free Univ. of Berlin (Germany)
+ Show Author Affiliations

It is fundamental for the flourishing biological cells that membrane proteins mediate the process. Membrane-embedded transporters move ions and larger solutes across membranes; receptors mediate communication between the cell and its environment and membrane-embedded enzymes catalyze chemical reactions. Understanding these mechanisms of action requires knowledge of how the proteins couple to their fluid, hydrated lipid membrane environment. Here, we present here current studies in computational and experimental membrane protein biophysics, and show how they address outstanding challenges in understanding the complex environmental effects on the structure, function, and dynamics of membrane proteins.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE; National Science Foundation (NSF)
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1265906
Journal Information:
Journal of Membrane Biology, Vol. 248, Issue 4; ISSN 0022-2631
Publisher:
SpringerCopyright Statement
Country of Publication:
United States
Language:
English
Citation Metrics:
Cited by: 116 works
Citation information provided by
Web of Science

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  • Ulmschneider, Martin B.; Doux, Jacques P. F.; Killian, J. Antoinette
  • Journal of the American Chemical Society, Vol. 132, Issue 10 https://doi.org/10.1021/ja909347x
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Ubiquitination and the Regulation of Membrane Proteins journal January 2017
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The outer membrane phospholipase A is essential for membrane integrity and type III secretion in Shigella flexneri journal September 2016
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REDOR NMR Reveals Multiple Conformers for a Protein Kinase C Ligand in a Membrane Environment journal January 2018
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Biological Membranes in Extreme Conditions: Simulations of Anionic Archaeal Tetraether Lipid Membranes journal May 2016
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