Nanoscale pillar arrays for separations

Kirchner, Teresa; Strickhouser, Rachel; Hatab, Nahla; Charlton, Jennifer; Kravchenko, Ivan I.; Lavrik, Nickolay V.; Sepaniak, Michael J.

doi:10.1039/C4AN02187H

Nanoscale pillar arrays for separations

Journal Article · Wed Apr 01 00:00:00 EDT 2015 · Analyst

DOI:https://doi.org/10.1039/C4AN02187H· OSTI ID:1265739

Kirchner, Teresa ^[1]; Strickhouser, Rachel ^[1]; Hatab, Nahla ^[1]; Charlton, Jennifer ^[2]; Kravchenko, Ivan I. ^[3]; Lavrik, Nickolay V. ^[3]; Sepaniak, Michael J. ^[3]

Univ. of Tennessee, Knoxville, TN (United States)
Univ. of Tennessee, Knoxville, TN (United States); Y-12 National Security Complex, Oak Ridge, TN (United States)
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

The work presented herein evaluates silicon nano-pillar arrays for use in planar chromatography. Electron beam lithography and metal thermal dewetting protocols were used to create nano-thin layer chromatography platforms. With these fabrication methods we are able to reduce the size of the characteristic features in a separation medium below that used in ultra-thin layer chromatography; i.e. pillar heights are 1-2μm and pillar diameters are typically in the 200- 400nm range. In addition to the intrinsic nanoscale aspects of the systems, it is shown they can be further functionalized with nanoporous layers and traditional stationary phases for chromatography; hence exhibit broad-ranging lab-on-a-chip and point-of-care potential. Because of an inherent high permeability and very small effective mass transfer distance between pillars, chromatographic efficiency can be very high but is enhanced herein by stacking during development and focusing while drying, yielding plate heights in the nm range separated band volumes. Practical separations of fluorescent dyes, fluorescently derivatized amines, and anti-tumor drugs are illustrated.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1265739

Journal Information:: Analyst, Journal Name: Analyst Journal Issue: 10 Vol. 140; ISSN 0003-2654

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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