Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering

Kučerka, Norbert; Heberle, Frederick A.; Pan, Jianjun; Katsaras, John

doi:10.3390/membranes5030454

Title: Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering

Journal Article · Mon Sep 21 00:00:00 EDT 2015 · Membranes

DOI:https://doi.org/10.3390/membranes5030454· OSTI ID:1265608

Kučerka, Norbert ^[1]; Heberle, Frederick A. ^[2]; Pan, Jianjun ^[3]; Katsaras, John ^[4]

Joint Inst. for Nuclear Research (JINR), Dubna (Russian Federation). Frank Lab. of Neutron Physics; Comenius Univ., Bratislava (Slovakia). Dept. of Physical Chemistry of Drugs
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences
Univ. of South Florida, Tampa, FL (United States). Dept. of Physics
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Biology and Soft Matter Division; Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Joint Inst. for Neutron Sciences; Univ. of Tennessee, Knoxville, TN (United States). Dept. of Physics and Astronomy

In this paper, we review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by the sometimes conflicting results found in the literature, even in the case of the most studied lipid bilayers. Increasingly, accurate and detailed structural models require more experimental data, such as those from contrast varied neutron scattering and X-ray scattering experiments that are jointly refined with molecular dynamics simulations. This experimental and computational approach produces robust bilayer structural parameters that enable insights, for example, into the interplay between collective membrane properties and its components (e.g., hydrocarbon chain length and unsaturation, and lipid headgroup composition). Finally, from model studies such as these, one is better able to appreciate how a real biological membrane can be tuned by balancing the contributions from the lipid’s different moieties (e.g., acyl chains, headgroups, backbones, etc.).

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES); Ministry of Education, Science, Research and Sport of the Slovak Republic (Slovakia); Joint Inst. for Nuclear Research (JINR) (Russian Federation)

Grant/Contract Number:: AC05-00OR22725; 1/1224/12; 04-4-1121-2015/2017

OSTI ID:: 1265608

Journal Information:: Membranes, Vol. 5, Issue 3; ISSN 2077-0375

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Structural Predictions of the SNX-RGS Proteins Suggest They Belong to a New Class of Lipid Transfer Proteins Paul, Blessy; Weeratunga, Saroja; Tillu, Vikas A. Frontiers in Cell and Developmental Biology, Vol. 10 https://doi.org/10.3389/fcell.2022.826688	journal	February 2022
Alcohol Interactions with Lipid Bilayers Kondela, Tomáš; Gallová, Jana; Hauß, Thomas Molecules, Vol. 22, Issue 12 https://doi.org/10.3390/molecules22122078	journal	November 2017
Localization and Orientation of Xanthophylls in a Lipid Bilayer Grudzinski, Wojciech; Nierzwicki, Lukasz; Welc, Renata Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-10183-7	journal	August 2017

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