Commentary on Inhaled 239PuO2 in Dogs — A Prophylaxis against Lung Cancer?

Cuttler, Jerry M.; Feinendegen, Ludwig E.

doi:10.2203/dose-response.15-003.Cuttler

Title: Commentary on Inhaled ²³⁹PuO₂ in Dogs — A Prophylaxis against Lung Cancer?

Journal Article · Thu Jan 01 00:00:00 EST 2015 · Dose-Response

DOI:https://doi.org/10.2203/dose-response.15-003.Cuttler· OSTI ID:1263484

Cuttler, Jerry M. ^[1]; Feinendegen, Ludwig E. ^[2]

Cuttler & Associates, Vaughan, ON (Canada)
Brookhaven National Lab. (BNL), Upton, NY (United States)

Several studies on the effect of inhaled plutonium-dioxide particulates and the incidence of lung tumors in dogs reveal beneficial effects when the cumulative alpha-radiation dose is low. There is a threshold at an exposure level of about 100 cGy for excess tumor incidence and reduced lifespan. The observations conform to the expectations of the radiation hormesis dose-response model and contradict the predictions of the LNT hypothesis. These studies suggest investigating the possibility of employing low-dose alpha-radiation, such as from ²³⁹PuO₂ inhalation, as a prophylaxis against lung cancer.

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Research Organization:: Brookhaven National Lab. (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE

OSTI ID:: 1263484

Journal Information:: Dose-Response, Vol. 13, Issue -1; ISSN 1559-3258

Publisher:: International Hormesis SocietyCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 2 works

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References (13)

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CARCINOGENESIS FROM INHALED 239PuO2 IN BEAGLES: EVIDENCE FOR RADIATION HOMEOSTASIS AT LOW DOSES? Fisher, Darrell R.; Weller, Richard E. Health Physics, Vol. 99, Issue 3 https://doi.org/10.1097/HP.0b013e3181bfa16b	journal	January 2010
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Meta-analysis of thirty-two case–control and two ecological radon studies of lung cancer Dobrzyński, Ludwik; Fornalski, Krzysztof W.; Reszczyńska, Joanna Journal of Radiation Research, Vol. 59, Issue 2 https://doi.org/10.1093/jrr/rrx061	journal	November 2017

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Title: Commentary on Inhaled ²³⁹PuO₂ in Dogs — A Prophylaxis against Lung Cancer?