Nuclear magnetic resonance characterization of the binding of peptides from HIV GP120 by heparin
- Univ. of California, Riverside, CA (United States)
Heparin has recently been shown to inhibit the growth and replication of human immunodeficiency virus, HIV. The inhibition of HIV by heparin is believed to be partly the result of its binding to envelope glycoprotein gp120 of the virus. Amino acids 307-330 of gp120 form a heparin-binding domain having the sequence: N-N-T-R-K-S-I-R-I-Q-R-G-P-G-R-A-F-V-T-I-G-K-I-G. This paper will present results on the characterization of the interaction of heparin with synthetic peptides derived from the heparin-binding domain of gp120 of HIV using one and two-dimensional nuclear magnetic resonance (NMR) spectroscopy. Information will be presented on the amino acid residues of the peptides that are involved in the binding to heparin, the nature of the interactions between heparin and these residues, and the structure of the peptides in the peptide-heparin complexes.
- OSTI ID:
- 126080
- Report Number(s):
- CONF-950402--
- Country of Publication:
- United States
- Language:
- English
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