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Title: Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice

Journal Article · · Nature Communications
DOI:https://doi.org/10.1038/ncomms9250· OSTI ID:1259894
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Research Organization:
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
FOREIGN
OSTI ID:
1259894
Journal Information:
Nature Communications, Vol. 6, Issue 2015; ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH

References (44)

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An Insulin-Degrading Enzyme Inhibitor Decreases Amylin Degradation, Increases Amylin-Induced Cytotoxicity, and Increases Amyloid Formation in Insulinoma Cell Cultures journal August 2003
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Deletion of the Fission Yeast Homologue of Human Insulinase Reveals a TORC1-Dependent Pathway Mediating Resistance to Proteotoxic Stress journal June 2013
Proteolytically Inactive Insulin-Degrading Enzyme Inhibits Amyloid Formation Yielding Non-Neurotoxic Aβ Peptide Aggregates journal April 2013
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Deletion of Insulin-Degrading Enzyme Elicits Antipodal, Age-Dependent Effects on Glucose and Insulin Tolerance journal June 2011
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Optimization of Peptide Hydroxamate Inhibitors of Insulin-Degrading Enzyme Reveals Marked Substrate-Selectivity journal March 2013
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Imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, substrate-dependent modulators of insulin-degrading enzyme in amyloid-β hydrolysis journal May 2014
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Cited By (12)

Preparation of Selenoinsulin as a Long-Lasting Insulin Analogue journal April 2017
Efforts towards an On‐Target Version of the Groebke–Blackburn–Bienaymé (GBB) Reaction for Discovery of Druglike Urokinase (uPA) Inhibitors journal August 2019
Bridging Type 2 Diabetes and Alzheimer's Disease: Assembling the Puzzle Pieces in the Quest for the Molecules With Therapeutic and Preventive Potential journal April 2017
The insulin-degrading enzyme is an allosteric modulator of the 20S proteasome and a potential competitor of the 19S journal March 2018
Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme journal May 2019
Multiple functions of insulin-degrading enzyme: a metabolic crosslight? journal June 2017
Pancreatic β-cell-specific deletion of insulin-degrading enzyme leads to dysregulated insulin secretion and β-cell functional immaturity journal November 2019
Ablation of amyloid precursor protein increases insulin-degrading enzyme levels and activity in brain and peripheral tissues journal January 2019
Drug Target Engagement Using Coupled Cellular Thermal Shift Assay—Acoustic Reverse-Phase Protein Array journal December 2019
Novel C15 Triene Triazole, D-A Derivatives Anti-HepG2, and as HDAC2 Inhibitors: A Synergy Study journal October 2018
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme text January 2018
Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme journal March 2018

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