X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

St. John, Sarah E.; Therkelsen, Matthew D.; Nyalapatla, Prasanth R.; Osswald, Heather L.; Ghosh, Arun K.; Mesecar, Andrew D.

doi:10.1016/j.bmcl.2015.10.023

Title: X-ray structure and inhibition of the feline infectious peritonitis virus 3C-like protease: Structural implications for drug design

Journal Article · Sun Nov 01 00:00:00 EDT 2015 · Bioorganic and Medicinal Chemistry Letters

DOI:https://doi.org/10.1016/j.bmcl.2015.10.023· OSTI ID:1250605

St. John, Sarah E.; Therkelsen, Matthew D.; Nyalapatla, Prasanth R.; Osswald, Heather L.; Ghosh, Arun K.; Mesecar, Andrew D.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1250605

Journal Information:: Bioorganic and Medicinal Chemistry Letters, Journal Name: Bioorganic and Medicinal Chemistry Letters Vol. 25 Journal Issue: 22; ISSN 0960-894X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United Kingdom

Language:: English

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Cited by: 13 works

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References (18)

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Genomic RNA sequence of Feline coronavirus strain FIPV WSU-79/1146 Dye, Charlotte; Siddell, Stuart G. Journal of General Virology, Vol. 86, Issue 8 https://doi.org/10.1099/vir.0.80985-0	journal	August 2005
Feline coronavirus antibodies in cats Addie, D.; Jarrett, J. Veterinary Record, Vol. 131, Issue 9 https://doi.org/10.1136/vr.131.9.202-a	journal	August 1992
Evaluating the 3C-like protease activity of SARS-Coronavirus: Recommendations for standardized assays for drug discovery Grum-Tokars, Valerie; Ratia, Kiira; Begaye, Adrian Virus Research, Vol. 133, Issue 1 https://doi.org/10.1016/j.virusres.2007.02.015	journal	April 2008
Feline infectious peritonitis Hartmann, Katrin Veterinary Clinics of North America: Small Animal Practice, Vol. 35, Issue 1 https://doi.org/10.1016/j.cvsm.2004.10.011	journal	January 2005
Exposure to FIV and FIPV in wild and captive cheetahs Brown, Eric W.; Olmsted, Robert A.; Martenson, Janice S. Zoo Biology, Vol. 12, Issue 1 https://doi.org/10.1002/zoo.1430120112	journal	January 1993
Broad-Spectrum Inhibitors against 3C-Like Proteases of Feline Coronaviruses and Feline Caliciviruses Kim, Yunjeong; Shivanna, Vinay; Narayanan, Sanjeev Journal of Virology, Vol. 89, Issue 9 https://doi.org/10.1128/JVI.03688-14	journal	February 2015
Morphogenesis of a virus in cats with experimental feline infectious peritonitis Ward, Jerrold M. Virology, Vol. 41, Issue 1 https://doi.org/10.1016/0042-6822(70)90070-X	journal	May 1970
Coot model-building tools for molecular graphics Emsley, Paul; Cowtan, Kevin Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132 https://doi.org/10.1107/S0907444904019158	journal	November 2004
Pathogenesis of feline enteric coronavirus infection Pedersen, Niels C.; Allen, Claire E.; Lyons, Leslie A. Journal of Feline Medicine and Surgery, Vol. 10, Issue 6 https://doi.org/10.1016/j.jfms.2008.02.006	journal	December 2008
Features and development of Coot Emsley, P.; Lohkamp, B.; Scott, W. G. Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 4 https://doi.org/10.1107/S0907444910007493	journal	March 2010
Design, synthesis, and bioevaluation of viral 3C and 3C-like protease inhibitors Prior, Allan M.; Kim, Yunjeong; Weerasekara, Sahani Bioorganic & Medicinal Chemistry Letters, Vol. 23, Issue 23 https://doi.org/10.1016/j.bmcl.2013.09.070	journal	December 2013
Feline Infectious Peritonitis Viruses Arise by Mutation from Endemic Feline Enteric Coronaviruses Vennema, Harry; Poland, Amy; Foley, Janet Virology, Vol. 243, Issue 1 https://doi.org/10.1006/viro.1998.9045	journal	March 1998
Completion of the Porcine Epidemic Diarrhoea Coronavirus (PEDV) Genome Sequence Kocherhans, Rolf; Bridgen, Anne; Ackermann, Mathias Virus Genes, Vol. 23, Issue 2, p. 137-144 https://doi.org/10.1023/A:1011831902219	journal	January 2001
Broad-Spectrum Antivirals against 3C or 3C-Like Proteases of Picornaviruses, Noroviruses, and Coronaviruses Kim, Y.; Lovell, S.; Tiew, K. -C. Journal of Virology, Vol. 86, Issue 21 https://doi.org/10.1128/JVI.01348-12	journal	August 2012
Pathogenic characteristics of persistent feline enteric coronavirus infection in cats Vogel, Liesbeth; Van der Lubben, Mariken; Te Lintelo, Eddie G. Veterinary Research, Vol. 41, Issue 5 https://doi.org/10.1051/vetres/2010043	journal	July 2010
Design and Synthesis of Peptidomimetic Severe Acute Respiratory Syndrome Chymotrypsin-like Protease Inhibitors Ghosh, Arun K.; Xi, Kai; Ratia, Kiira Journal of Medicinal Chemistry, Vol. 48, Issue 22 https://doi.org/10.1021/jm050548m	journal	November 2005
PHENIX: a comprehensive Python-based system for macromolecular structure solution Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221 https://doi.org/10.1107/S0907444909052925	journal	January 2010

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