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Title: Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties

Journal Article · · Bioorganic and Medicinal Chemistry Letters
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Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1250357
Journal Information:
Bioorganic and Medicinal Chemistry Letters, Journal Name: Bioorganic and Medicinal Chemistry Letters Vol. 25 Journal Issue: 7; ISSN 0960-894X
Publisher:
ElsevierCopyright Statement
Country of Publication:
United Kingdom
Language:
English
Citation Metrics:
Cited by: 31 works
Citation information provided by
Web of Science

References (25)

Factor XIa and tissue factor activity in patients with coronary artery disease journal January 2008
Phenylimidazoles as Potent and Selective Inhibitors of Coagulation Factor XIa with in Vivo Antithrombotic Activity journal November 2014
Intrinsic Pathway of Coagulation and Arterial Thrombosis journal December 2007
Discovery of the Novel Antithrombotic Agent 5-Chloro- N -({(5 S )-2-oxo-3- [4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene- 2-carboxamide (BAY 59-7939):  An Oral, Direct Factor Xa Inhibitor journal September 2005
The Discovery of (2R,4R)-N-(4-chlorophenyl)-N- (2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)-4-methoxypyrrolidine-1,2-dicarboxamide (PD 0348292), an Orally Efficacious Factor Xa Inhibitor journal August 2007
A murine model of factor XI deficiency journal January 1997
Discovery of 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro- 1 H -pyrazolo[3,4- c ]pyridine-3-carboxamide (Apixaban, BMS-562247), a Highly Potent, Selective, Efficacious, and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa journal November 2007
Elevated Factor XI Activity Levels Are Associated With an Increased Odds Ratio for Cerebrovascular Events journal September 2006
The discovery and development of rivaroxaban, an oral, direct factor Xa inhibitor journal December 2010
Discovery of an Orally Efficacious Inhibitor of Coagulation Factor Xa Which Incorporates a Neutral P 1 Ligand journal February 2003
Oral Apixaban for the Treatment of Acute Venous Thromboembolism journal August 2013
The intrinsic pathway of coagulation: a target for treating thromboembolic disease? journal June 2007
Tetrahydroquinoline Derivatives as Potent and Selective Factor XIa Inhibitors journal January 2014
Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk journal November 2010
Inherited factor XI deficiency: A concise review journal October 2006
Effects of factor IX or factor XI deficiency on ferric chloride-induced carotid artery occlusion in mice: Thrombosis in FIX- and FXI-deficient mice journal February 2005
Discovery and Evaluation of Potent P 1 Aryl Heterocycle-Based Thrombin Inhibitors journal June 2004
Discovery of 1-(3‘-Aminobenzisoxazol-5‘-yl)-3-trifluoromethyl- N -[2-fluoro-4- [(2‘-dimethylaminomethyl)imidazol-1-yl]phenyl]-1 H -pyrazole-5-carboxyamide Hydrochloride (Razaxaban), a Highly Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor journal March 2005
Concise Preparation of Amino-5,6,7,8-tetrahydroquinolines and Amino-5,6,7,8-tetrahydroisoquinolines via Catalytic Hydrogenation of Acetamidoquinolines and Acetamidoisoquinolines journal November 2002
Arterial thrombosis—insidious, unpredictable and deadly journal November 2011
Dabigatran versus Warfarin in the Treatment of Acute Venous Thromboembolism journal December 2009
Factor Xa Inhibitors: Next-Generation Antithrombotic Agents journal September 2010
Structure-Based Design of Novel Guanidine/Benzamidine Mimics:  Potent and Orally Bioavailable Factor Xa Inhibitors as Novel Anticoagulants journal October 2003
Inhibition of Factor XIa as a New Approach to Anticoagulation journal March 2010
A small-molecule factor XIa inhibitor produces antithrombotic efficacy with minimal bleeding time prolongation in rabbits journal May 2011

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