Evidence for an Intermediate in Myosin Hydrolysis
Conference
·
OSTI ID:12491016
Ever since the hydrolysis of ATP by myosin was discovered the mechanism of this reaction has been a subject of intensive research. In some way the energy of the phosphate bond must be transferred to muscle protein so that chemical energy can ge transformed into mechanical work. Formation of a phosphoryl-myosin intermediate has been suggested by many workers but evidence for such an intermediate has been elusive. ADP-32-ATP exchanges gave negative results and no P32-labeled myosin, other than that absorbed by non-covalent forces, has yet been identified with the hydrolysis reaction.
- Research Organization:
- Brookhaven National Laboratory (BNL), Upton, NY (United States); New York Univ., New York, NY (United States)
- Sponsoring Organization:
- US Atomic Energy Commission (AEC)
- DOE Contract Number:
- AT(30-2)-GEN-16
- OSTI ID:
- 12491016
- Report Number(s):
- BNL--6418
- Country of Publication:
- United States
- Language:
- English
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