Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging

Rose-Petruck, Christoph; Wands, Jack R.; Rand, Danielle; Derdak, Zoltan; Ortiz, Vivian

Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging

Patent · 19 April 2016

OSTI ID:1247995

Rose-Petruck, Christoph; Wands, Jack R.; Rand, Danielle; Derdak, Zoltan; Ortiz, Vivian

Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.

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Research Organization:: BROWN UNIVERSITY, Providence, RI (United States) RHODE ISLAND HOSPITAL, Providence, RI (United States)

Sponsoring Organization:: USDOE

DOE Contract Number:: FG02-08ER15937;

Assignee:: BROWN UNIVERSITY (Providence, RI) RHODE ISLAND HOSPITAL (Providence, RI)

Patent Number(s):: 9,316,645

Application Number:: 13/645,938

OSTI ID:: 1247995

Country of Publication:: United States

Language:: English

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Methods, compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging

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