Bcl-2 and the regulation of programmed cell death
|
journal
|
January 1994 |
Cell Death
|
journal
|
January 2004 |
The Hallmarks of Cancer
|
journal
|
January 2000 |
Hallmarks of Cancer: The Next Generation
|
journal
|
March 2011 |
Caspase-dependent apoptosis of COS-7 cells induced by Bax overexpression: differential effects of Bcl-2 and Bcl-xL on Bax-induced caspase activation and apoptosis
|
journal
|
October 1997 |
The Bcl-2 apoptotic switch in cancer development and therapy
|
journal
|
February 2007 |
Death and anti-death: tumour resistance to apoptosis
|
journal
|
April 2002 |
Targeting Apoptosis Pathways in Cancer Therapy
|
journal
|
May 2005 |
The BCL-2 protein family, BH3-mimetics and cancer therapy
|
journal
|
May 2015 |
ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor
|
journal
|
May 2008 |
Mechanism-based pharmacokinetic/pharmacodynamic meta-analysis of navitoclax (ABT-263) induced thrombocytopenia
|
journal
|
July 2014 |
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
|
journal
|
January 2013 |
Discovery of Potent Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods and Structure-Based Design
|
journal
|
December 2012 |
Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity
|
journal
|
February 2015 |
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
|
journal
|
January 2015 |
Discovery of Tricyclic Indoles That Potently Inhibit Mcl-1 Using Fragment-Based Methods and Structure-Based Design
|
journal
|
April 2015 |
3-Substituted- N -(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation
|
journal
|
May 2014 |
Fragment-based discovery of potent inhibitors of the anti-apoptotic MCL-1 protein
|
journal
|
March 2014 |
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
|
journal
|
November 2006 |
‘Seed’ analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737
|
journal
|
December 2006 |
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
|
journal
|
March 2011 |
Inducing apoptosis and enhancing chemosensitivity to Gemcitabine via RNA interference targeting Mcl-1 gene in pancreatic carcinoma cell
|
journal
|
February 2008 |
The landscape of somatic copy-number alteration across human cancers
|
journal
|
February 2010 |
A survey of the anti-apoptotic Bcl-2 subfamily expression in cancer types provides a platform to predict the efficacy of Bcl-2 antagonists in cancer therapy
|
journal
|
May 2010 |
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
|
journal
|
April 2004 |
Structural biology of the Bcl-2 family of proteins
|
journal
|
March 2004 |
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy
|
journal
|
December 2013 |
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
|
journal
|
June 2010 |
Structural insights into the degradation of Mcl-1 induced by BH3 domains
|
journal
|
March 2007 |
Discovering High-Affinity Ligands for Proteins: SAR by NMR
|
journal
|
November 1996 |
Profiling drug-like properties in discovery research
|
journal
|
June 2003 |
Rational Use of Plasma Protein and Tissue Binding Data in Drug Design: Miniperspective
|
journal
|
August 2014 |
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
|
journal
|
May 2005 |
Myeloid cell leukemia-1 is an important apoptotic survival factor in triple-negative breast cancer
|
journal
|
June 2015 |
[20] Processing of X-ray diffraction data collected in oscillation mode
|
book
|
January 1997 |
Phaser crystallographic software
|
journal
|
July 2007 |
The CCP4 suite programs for protein crystallography
|
journal
|
September 1994 |
Coot model-building tools for molecular graphics
|
journal
|
November 2004 |
Development and optimization of a binding assay for the XIAP BIR3 domain using fluorescence polarization
|
journal
|
September 2004 |