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Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

Journal Article · · Cell
Abstract not provided
Research Organization:
Advanced Photon Source (APS), Argonne National Laboratory (ANL), Argonne, IL (US)
Sponsoring Organization:
NIHNIAIDOTHER
OSTI ID:
1247358
Journal Information:
Cell, Journal Name: Cell Journal Issue: (2) ; 04, 2016 Vol. 165; ISSN 0092-8674
Country of Publication:
United States
Language:
ENGLISH

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Recent progress in broadly neutralizing antibodies to HIV journal October 2018
Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses journal November 2019
Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearance journal May 2017
Increased breadth of HIV-1 neutralization achieved by diverse antibody clones each with limited neutralization breadth journal December 2018
In-Depth Analysis of Human Neonatal and Adult IgM Antibody Repertoires journal February 2018
Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site journal August 2016
Immunologic characteristics of HIV-infected individuals who make broadly neutralizing antibodies journal January 2017
Learning the heterogeneous hypermutation landscape of immunoglobulins from high-throughput repertoire data journal October 2020
Native-like Env trimers as a platform for HIV-1 vaccine design journal January 2017
Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting journal January 2017
Antibody-virus co-evolution in HIV infection: paths for HIV vaccine development journal January 2017
Selection of immunoglobulin elbow region mutations impacts interdomain conformational flexibility in HIV-1 broadly neutralizing antibodies journal February 2019
Fine epitope signature of antibody neutralization breadth at the HIV-1 envelope CD4-binding site journal March 2018
Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection journal May 2018
Progress toward active or passive HIV-1 vaccination journal December 2016
HIV-1 vaccine design through minimizing envelope metastability journal November 2018
Improvement of antibody functionality by structure-guided paratope engraftment journal February 2019
Tfh cells and HIV bnAbs, an immunodominance model of the HIV neutralizing antibody generation problem journal January 2017
Antibody responses to viral infections: a structural perspective across three different enveloped viruses journal March 2019
HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies journal November 2018
Targeted selection of HIV-specific antibody mutations by engineering B cell maturation journal December 2019
Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site journal September 2016
Envelope residue 375 substitutions in simian–human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques journal May 2016
A human inferred germline antibody binds to an immunodominant epitope and neutralizes Zika virus journal June 2017
Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting journal April 2019
Human adaptive immune receptor repertoire analysis-Past, present, and future journal June 2018
HIV-1 immunogens and strategies to drive antibody responses towards neutralization breadth journal November 2018
Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density journal March 2018
Anti-idiotypic antibodies elicit anti-HIV-1–specific B cell responses journal July 2019
Aberrant B cell repertoire selection associated with HIV neutralizing antibody breadth journal January 2020
Mechanisms of Adaptive Immunity to Porcine Reproductive and Respiratory Syndrome Virus journal June 2017
Exposure of an occluded hemagglutinin epitope drives selection of a class of cross-protective influenza antibodies journal August 2019
Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy? text January 2018
Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage journal September 2019
An HIV-1 broadly neutralizing antibody from a clade C infected pediatric elite neutralizer potently neutralizes the contemporaneous and autologous evolving viruses posted_content August 2018
Exploiting B Cell Receptor Analyses to Inform on HIV-1 Vaccination Strategies journal January 2020
Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller journal January 2017
Ancestral sequences from an elite neutralizer proximal to the development of neutralization resistance as a potential source of HIV vaccine immunogens journal April 2019
Germline-targeting immunogens journal January 2017
Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies journal February 2018
Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation journal May 2017
Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies journal September 2019
Staged induction of HIV-1 glycan–dependent broadly neutralizing antibodies journal March 2017
Observed Antibody Space: A Resource for Data Mining Next-Generation Sequencing of Antibody Repertoires journal September 2018
Use of broadly neutralizing antibodies for HIV-1 prevention journal January 2017
Development of broadly neutralizing antibodies in HIV-1 infected elite neutralizers journal September 2018
Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design journal August 2018
Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy? journal July 2018
Development of Antibodies with Broad Neutralization Specificities against HIV-1 after Long Term SHIV Infection in Macaques journal January 2020
The role of follicular helper CD4 T cells in the development of HIV-1 specific broadly neutralizing antibody responses journal August 2018

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Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody
Journal Article · Thu Mar 31 20:00:00 EDT 2016 · Cell · OSTI ID:1350149

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