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Capillary absorption spectrometer and process for isotopic analysis of small samples

Patent ·
OSTI ID:1244233
; ; ; ; ;

A capillary absorption spectrometer and process are described that provide highly sensitive and accurate stable absorption measurements of analytes in a sample gas that may include isotopologues of carbon and oxygen obtained from gas and biological samples. It further provides isotopic images of microbial communities that allow tracking of nutrients at the single cell level. It further targets naturally occurring variations in carbon and oxygen isotopes that avoids need for expensive isotopically labeled mixtures which allows study of samples taken from the field without modification. The method also permits sampling in vivo permitting real-time ambient studies of microbial communities.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
Assignee:
BATTELLE MEMORIAL INSTITUTE (Richland, WA)
Patent Number(s):
9,297,756
Application Number:
13/757,460
OSTI ID:
1244233
Country of Publication:
United States
Language:
English

References (6)

Laser ablation-combustion-GC-IRMS--a new method for online analysis of intra-annual variation of  13C in tree rings journal November 2004
Laser ablation isotope ratio mass spectrometry for enhanced sensitivity and spatial resolution in stable isotope analysis: LA-IRMS for enhanced sensitivity in stable isotope analysis journal April 2011
New method for isotopic ratio measurements of atmospheric carbon dioxide using a 4.3 μm pulsed quantum cascade laser journal January 2008
A capillary absorption spectrometer for stable carbon isotope ratio (13C/12C) analysis in very small samples journal February 2012
Absorption spectroscopy in hollow-glass waveguides using infrared diode lasers
  • Blake, Thomas A.; Kelly, James F.; Stewart, Timothy L.
  • International Symposium on Optical Science and Technology, SPIE Proceedings https://doi.org/10.1117/12.453761
conference September 2002
High-precision optical measurements of 13C/12C isotope ratios in organic compounds at natural abundance journal June 2009

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