Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations

Chen, Tsung-Chi; Ibrahim, Yehia M.; Webb, Ian K.; Garimella, Sandilya V. B.; Zhang, Xing; Hamid, Ahmed M.; Deng, Liulin; Karnesky, William E.; Prost, Spencer A.; Sandoval, Jeremy A.; Norheim, Randolph V.; Anderson, Gordon A.; Tolmachev, Aleksey V.; Baker, Erin Shammel; Smith, Richard D.

doi:10.1021/acs.analchem.5b03910

Mobility-Selected Ion Trapping and Enrichment Using Structures for Lossless Ion Manipulations

Journal Article · Sun Jan 10 23:00:00 EST 2016 · Analytical Chemistry

DOI:https://doi.org/10.1021/acs.analchem.5b03910· OSTI ID:1243166

Chen, Tsung-Chi ^[1]; Ibrahim, Yehia M. ^[1]; Webb, Ian K. ^[1]; Garimella, Sandilya V. B. ^[1]; Zhang, Xing ^[1]; Hamid, Ahmed M. ^[1]; Deng, Liulin ^[1]; Karnesky, William E. ^[1]; Prost, Spencer A. ^[1]; Sandoval, Jeremy A. ^[1]; Norheim, Randolph V. ^[1]; Anderson, Gordon A. ^[1]; Tolmachev, Aleksey V. ^[1]; Baker, Erin Shammel ^[1]; Smith, Richard D. ^[1]

Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division

The integration of ion mobility spectrometry (IMS) with mass spectrometry (MS) and the ability to trap ions in IMS-MS measurements is of great importance for performing reactions, accumulating ions, and increasing analytical measurement sensitivity. The development of Structures for Lossless Ion Manipulations (SLIM) offers the potential for ion manipulations in a more reliable and cost-effective manner, while opening opportunities for much more complex sequences of manipulations. Here, we demonstrate an ion separation and trapping module and a method based upon SLIM that consists of a linear mobility ion drift region, a switch/tee and a trapping region that allows the isolation and accumulation of mobility-separated species. The operation and optimization of the SLIM switch/tee and trap are described and demonstrated for the enrichment of the low abundance ions. Lastly, we observed a linear increase in ion intensity with the number of trapping/accumulation events using the SLIM trap, illustrating its potential for enhancing the sensitivity of low abundance or targeted species.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (US), Environmental Molecular Sciences Laboratory (EMSL)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 1243166

Report Number(s):: PNNL-SA--113681; 48680; 48135; KP1601010

Journal Information:: Analytical Chemistry, Journal Name: Analytical Chemistry Journal Issue: 3 Vol. 88; ISSN 0003-2700

Publisher:: American Chemical Society (ACS)Copyright Statement

Country of Publication:: United States

Language:: English

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Nanowell-mediated multidimensional separations combining nanoLC with SLIM IM-MS for rapid, high-peak-capacity proteomic analyses Dou, Maowei; Chouinard, Christopher D.; Zhu, Ying Analytical and Bioanalytical Chemistry, Vol. 411, Issue 21 https://doi.org/10.1007/s00216-018-1452-5	journal	November 2018
New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells Couvillion, Sneha P.; Zhu, Ying; Nagy, Gabe The Analyst, Vol. 144, Issue 3 https://doi.org/10.1039/c8an01574k	journal	January 2019
A parallelized molecular collision cross section package with optimized accuracy and efficiency Ieritano, Christian; Crouse, Jeff; Campbell, J. Larry The Analyst, Vol. 144, Issue 5 https://doi.org/10.1039/c8an02150c	journal	January 2019
A simulation study of the influence of the traveling wave patterns on ion mobility separations in structures for lossless ion manipulations Li, Ailin; Garimella, Sandilya V. B.; Ibrahim, Yehia M. The Analyst, Vol. 145, Issue 1 https://doi.org/10.1039/c9an01509d	journal	January 2020

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