A multi-stimuli responive, self-assembling, boronic acid dipeptide

Jones, Brad Howard; Martinez, Alina Marissa; Wheeler, Jill S.; McKenzie, Bonnie B.; Miller, Lance Lee; Wheeler, David R.; Spoerke, Erik David

doi:10.1039/C5CC05207F

A multi-stimuli responive, self-assembling, boronic acid dipeptide

Journal Article · Tue Aug 11 00:00:00 EDT 2015 · ChemComm

DOI:https://doi.org/10.1039/C5CC05207F· OSTI ID:1235358

Jones, Brad Howard ^[1]; Martinez, Alina Marissa ^[1]; Wheeler, Jill S. ^[1]; McKenzie, Bonnie B. ^[1]; Miller, Lance Lee ^[1]; Wheeler, David R. ^[1]; Spoerke, Erik David ^[1]

Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Modification of the dipeptide of phenylalanine, FF, with a boronic acid (BA) functionality imparts unique aqueous self-assembly behavior that responds to multiple stimuli. Changes in pH and ionic strength are used to trigger hydrogelation via the formation of nanoribbon networks. Thus, we show for the first time that the binding of polyols to the BA functionality can modulate a peptide between its assembled and disassembled states.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC04-94AL85000

OSTI ID:: 1235358

Report Number(s):: SAND--2015-1901J; 579544

Journal Information:: ChemComm, Journal Name: ChemComm Journal Issue: 77 Vol. 51; ISSN CHCOFS; ISSN 1359-7345

Publisher:: Royal Society of ChemistryCopyright Statement

Country of Publication:: United States

Language:: English

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